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Environment


Purdue researchers found that honeybees collect pollen from a wide range of plants, even in areas dominated by corn and soybeans.
A Purdue University study shows that honeybees collect the vast majority of their pollen from plants other than crops, even in areas dominated by corn and soybeans, and that pollen is consistently contaminated with a host of agricultural and urban pesticides throughout the growing season.

Molecular & Cell Biology

New research by Steven Laviolette's research team at Western University is contributing to a better understanding of the ways opiate-class drugs modify brain circuits to drive the addiction cycle. Using rodent models of opiate addiction, Dr. Laviolette's research has shown that opiates affect pathways of associative memory formation in multiple ways, both at the level of anatomy (connections between neurons) and at the molecular levels (how molecules inside the brain affect these connections). The identification of these opiate-induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction. These results were presented at the 10th Annual Canadian Neuroscience Meeting, taking place May 29 to June 1 2016, in Toronto, Canada.

Biotechnology

Researchers from Bochum have engineered a hydrogen-producing enzyme in the test tube that works as efficiently as the original. The protein - a so-called hydrogenase from green algae - is made up of a protein scaffold and a cofactor. The latter is the reaction centre where the substances that react with each other dock. When the researchers added various chemically synthesised substances to the protein scaffold, the cofactor spontaneously assembled.

Health & Medicine

A benign virus normally found in the skin can lead to a type of rare, lethal skin cancer. Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. Researchers have now identified a type of skin cell as the target of the virus in humans. This study, from the Perelman School of Medicine at the University of Pennsylvania, establishes a new way to investigate this type of oncogenic viral infection and identifies a potential therapeutic agent against Merkel cell polyomavirus infection.

Biology


Hemiphlebia mirabilis is a rare species in every sense: it is the most primitive dragonfly known to man, it has unique reproductive behaviors and was believed to be extinct.
The dragonfly considered the most primitive in the world lives in Australia and Tasmania, and was believed to be extinct four decades ago. But it is far from being so. A Spanish researcher has observed thousands of these insects in one of the few habitats in which it has been detected and it displays sexual behaviour that is unique, not only directed towards reproduction.

Biology


This is the male fiddler crab Uca lactea.
The vibrations and pulses that male fiddler crabs produce when they are trying to lure females into their burrows to mate are surprisingly informative. These signals serve as a type of "Morse code" that the females decipher to learn more about the size and stamina of their suitors. This is according to a study by Japanese researchers Fumio Takeshita of Nagasaki University and Minoru Murai of the University of the Ryukyu, published in Springer's journal The Science of Nature.

Biotechnology


This is the herringbone structure of the outer layer (impact region) of the mantis shrimp dactyl club.
The next generation of airplanes, body armor and football helmets crawled out from under a rock--literally.

Biotechnology

The use of next-generation gene sequencing in newborns in neonatal intensive care units (NICUs) may improve the diagnosis of rare diseases and deliver results more quickly to anxious families, according to new research in CMAJ (Canadian Medical Association Journal).

Health & Medicine

Early exposure to nicotine can trigger widespread genetic changes that affect formation of connections between brain cells long after birth, a new Yale-led study has found. The finding helps explains why maternal smoking has been linked to behavioral changes such as attention deficit and hyperactivity disorder, addiction and conduct disorder.

Molecular & Cell Biology

Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer.

Molecular & Cell Biology

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus--the brain's memory center--temporal ordering of the neural code is important for building a mental map of where you've been, where you are, and where you are going. Published on May 30 in Nature Neuroscience, research from the RIKEN Brain Science Institute in Japan has pinpointed how the neurons that represent space in mice stay in time.

Molecular & Cell Biology


Tailor-made ratiometric sensors make baker's yeast cells light up green, as Georgia Tech scientists use it to track the movements of the essential toxin heme.
A pinch of poison is good for a body, at least if it's heme.

Molecular & Cell Biology


Stylized graphic of SEC-SAXS data (with cyan cross-section showing the elution profile and magenta cross-section showing scattering profile) and the structure of the activated phenylalanine hydroxylase
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health. The enzyme, phenylalanine hydroxylase, turns the essential amino acid phenylalanine -- found in eggs, beef and many other foods and as an additive in diet soda -- into tyrosine, a precursor for multiple important neurotransmitters.

Molecular & Cell Biology

A new study from MIT neuroscientists reveals that a gene mutation associated with autism plays a critical role in the formation and maturation of synapses -- the connections that allow neurons to communicate with each other.

Bioinformatics


This image shows a range of vertebrate the G10K members are working on: Bird - Ruby-throated Hummingbird; Reptile - Green Anole; Fish - Spotted Gar; Mammal - Koala
The Genome Analysis Centre (TGAC) are to hold the biannual Genome 10K Conference on 29 August - 1 September 2017.

Health & Medicine

The National Myelodysplastic Syndromes Natural History Study (The National MDS Study) is underway, the ECOG-ACRIN Cancer Research Group and its collaborators announced today. This new study, funded by the National Institutes of Health's National Heart, Lung, and Blood Institute (NHLBI), and performed in collaboration with the National Cancer Institute (NCI), will collect detailed information and biological samples from 2000 adults with myelodysplastic syndromes (MDS) and 500 more patients receiving care for a persistent low red blood cell count (anemia) that cannot be explained. Its purpose is to build a national resource to be used by scientists in future research.

Molecular & Cell Biology

Unlike aspirin, bone marrow doesn't come with a neatly printed label with dosage instructions. However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

AIDS & HIV

Viruses attack cells and commandeer their machinery in a complex and carefully orchestrated invasion. Scientists have longed probed this process for insights into biology and disease, but essential details still remain out of reach.

Molecular & Cell Biology


These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end...
A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

Bioinformatics

Whole-exome sequencing of both colorectal adenomas (precancers often called polyps) and intestinal mucosa at risk for developing into adenomas from patients with familial adenomatous polyposis (FAP) has generated a comprehensive picture of the genomic alterations that characterize the evolution of normal mucosa to precancer.

Health & Medicine

A change in diet can improve the lives of those diagnosed with a common, but hard-to-treat gut disorder.

Molecular & Cell Biology

Voltage-gated calcium channels open in unison, rather than independently, to allow calcium ions into and activate excitable cells such as neurons and muscle cells, researchers with UC Davis Health System and the University of Washington have found.

AIDS & HIV

Acute HIV infection (AHI) contributes significantly to HIV transmission and may be important for intervention strategies seeking to reduce incidence and achieve a functional cure. In a study by the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, published in The New England Journal of Medicine, scientists enrolled and intensively followed a cohort of high-risk individuals, tracking their HIV status and characterizing the disease through the acute stages of HIV infection.

Health & Medicine

Some of the final cases of Ebola in Sierra Leone were transmitted via unconventional routes, such as semen and breastmilk, according to the largest analysis to date of the tail-end of the epidemic.

Molecular & Cell Biology

Retroviral DNAs integrate into host genomes, but their expression is normally repressed by cellular defense mechanisms. As an Ludwig-Maximilians-Universitaet (LMU) in Munich team now shows, when these measures fail, accumulation of viral proteins may trigger programmed cell death.

Biology


Male and female worms engage in different behaviors, which may result from sex-specific wiring patterns in the brain.
Nematode worms may not be from Mars or Venus, but they do have sex-specific circuits in their brains that cause the males and females to act differently. According to new research published in Nature, scientists have determined how these sexually dimorphic (occurring in either males or females) connections arise in the worm nervous system. The research was funded by the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Microbiology

Australian scientists may have found a way to stop deadly bacteria from infecting patients. The discovery could lead to a whole new way of treating antibiotic-resistant "superbugs". The researchers have uncovered what may be an Achilles heel on the bacteria cell membrane that could act as a potential novel drug target.

Health & Medicine


In some cancers, including chondroblastoma and a rare form of childhood sarcoma, a mutation in histone H3 reduces global levels of methylation (dark areas) in tumor cells
A mutation that affects the proteins that package DNA--without changing the DNA itself--can cause a rare form of cancer, according to new findings in this week's Science from researchers at The Rockefeller University.

Molecular & Cell Biology


Verrucosispora maris, the bacteria in which the enzyme was found.
Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the 'Mona Lisa of chemical reactions' - in a bacterium that lives at the bottom of the Pacific Ocean.

Biology


This is a male specimen of the new long-horned beetle species Borneostyrax cristatus gen. et sp. nov.
A remarkably high diversity of the wingless long-horned beetles in the mountains of northern Borneo is reported by three Czech researchers from the Palacký University, Olomouc, Czech Republic. Apart from the genera and species new to science, the entomologists report the first case of reproduction by live birth in this rarely collected group of beetles.

Biotechnology


Close-up of the MinION handheld DNA sequencer.
A team from the University of Leicester has been awarded a prize for their proposal to crack down on wildlife crime using a portable DNA sequencing device, the MinION - developed by Oxford Nanopore Technologies - to read the 'barcode genes' of animals affected by illegal trafficking.

Health & Medicine


A cryo-electron microscopy image of the Zika virus structure.
Researchers at Washington University in St. Louis (WashU) have established the first models of Zika virus transmission from a pregnant mouse to her fetus. The infected mice, described May 11 in Cell, demonstrate Zika virus invasion and damage to the placenta, and then infection of the mouse fetus, leading to many of the same conditions observed in human infants. The new mouse models can also be used as a tool to develop treatments or vaccines.

Health & Medicine


This photo demonstrates the difference in size in Zika virus-infected vs. uninfected fetal mouse brains.
Mouse fetuses injected with the Asian Zika virus strain and carried to term within their pregnant mothers display the characteristic features of microcephaly, researchers in China report May 11 in Cell Stem Cell. As expected, the virus infected the neural progenitor cells, and infected brains reveal expression of genes related to viral entry, altered immune response, and cell death. The authors say this is direct evidence that Zika infection causes microcephaly in a mammalian animal model.

Molecular & Cell Biology

A new study finds that the more than 90,000 species of mushrooms, molds, yeasts and other fungi found everywhere in the soil, water and air may owe their abilities to grow, spread, and even cause disease to an opportunistic virus they caught more than a billion years ago.

Stem Cell Research

Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient's own adult cells, guaranteeing compatibility. However, the technique that turns adult cells into these iPS cells is not foolproof; after reverting to their pluripotent state, these cells don't always correctly differentiate back into adult cells.

Biology


Fossil and reconstruction of Atopodentatus unicus.
Some strange creatures cropped up in the wake of one of Earth's biggest mass extinctions 252 million years ago. In 2014, scientists discovered a bizarre fossil--a crocodile-sized sea-dwelling reptile, Atopodentatus unicus, that lived 242 million years ago in what today is southwestern China. Its head was poorly preserved, but it seemed to have a flamingo-like beak. However, in a paper published May 6 in Science Advances, Dr. LI Chun, Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences, and his international team described two new specimens and revealed what was really going on--that "beak" is actually part of a hammerhead-shaped jaw apparatus, which it used to feed on plants on the ocean floor. It's the earliest known example of an herbivorous marine reptile.

Molecular & Cell Biology


This is a tomographical slice of a budding yeast cell defective in condensin function (ycg1-2). The division septum advances on incompletely segregated chromosomes.
The cells in our bodies are constantly dividing. From embryonic development to adult life, cell division is necessary for tissue growth and renewal. During division, cells must duplicate their genetic material (or DNA) and ensure identical copies are passed along to the daughter cells. The entire process must work perfectly. If not, the next generation of cells will not have the genetic material necessary to function properly. Their role becomes especially relevant in situations in which cells proliferate rapidly, like embryonic development or tumor proliferation.

Molecular & Cell Biology


This is a snapping turtle.
The sex of many reptile species is set by temperature. New research reported in the journal GENETICS identifies the first gene associated with temperature-dependent sex determination in any reptile. Variation at this gene in snapping turtles contributes to geographic differences in the way sex ratio is influenced by temperature. Understanding the genetics of sex determination could help predict how reptiles will evolve in response to climate change.

Molecular & Cell Biology


A 3-D rendering of a fluorescence image maps the piconewton forces applied by T cells. The height and color indicates the magnitude of the applied force.
T cells, the security guards of the immune system, use a kind of mechanical "handshake" to test whether a cell they encounter is a friend or foe, a new study finds.

Biology


Evan R. Buechley releases an adult Egyptian Vulture in Armenia after tagging it with a satellite tracking device (visible on the back of the bird).
Vultures. Cartoon characters in parched deserts often wish them to disappear, since circling vultures are a stereotypical harbinger of death. But, joking aside, vultures in some parts of the world are in danger of disappearing. And according to a new report from University of Utah biologists, such a loss would have serious consequences for ecosystems and human populations alike.