Biology News Net
Bioinformatics

Category: Bioinformatics

Scientists at The Genome Institute of Singapore (GIS) and The Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development.

Together with colleagues in Barcelona, researchers at the University of North Carolina at Chapel Hill have generated a complete map of the areas of the genome that control which genes are "turned on" or "off." The discovery, made in pancreatic islet cells, opens new avenues for understanding the genetic basis of type 2 diabetes and other common illnesses.

In 2009, soybeans represented an almost $30 billion industry in the U.S. alone, making soybeans the second-most profitable crop next to corn. Worldwide, soybeans have been used in human foods and livestock feed for centuries and have been a key component in industrial products, such as plastics and soy biodiesel, an environmentally friendly fuel. A team of researchers, including University of Missouri researchers, recently completed a study identifying 1.1 million base pairs of DNA in the soybean genome, including more than 90 distinct traits that affect plant development, productive characteristics, disease resistance, seed quality and nutrition, which could lead to extensive crop improvements.

When fully grown they have a diminutive size of only 1-2 mm: the "Nasonia" wasps. But great hopes are drawn from them. Nasonia are parasitic insects infesting fly pupae. By doing so, they are naturally eliminating important agricultural pests. In order to provide constant supply of food for its offspring, the wasp must prevent the early death of the host flies – not less then 40-50 eggs are laid into each pupa. As biological pest control Nasonia is not yet perfect. But this could be changed in the future by using genetic engineering since the whole genome of Nasonia has been decoded by an international team of researchers supported by zoologists from Jena University. Their findings will be published in this Friday's issue of the well renowned journal „Science" (15/01/2010). "We now have the fully elaborated genome of Nasonia at our disposal," says Dr. Reinhard Predel from the Friedrich-Schiller-University Jena, pleased about it.

Soybean, one of the most important global sources of protein and oil, is now the first legume species with a published complete draft genome sequence. The sequence and its analysis appear in the January 14 edition of the journal Nature. The research team comprised 18 institutions, including the U.S. Department of Energy Joint Genome Institute (DOE JGI), the U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS), Purdue University and the University of North Carolina at Charlotte. The DOE, National Science Foundation, USDA and United Soybean Board supported the research.

As agricultural land becomes increasingly valuable, the need to maximize its utilization increases and decisions about what crops to plant and where, become paramount.

Research teams led by the Wellcome Trust Sanger Institute announce the first comprehensive analyses of cancer genomes.

The Singapore laboratory that deciphered the DNA codes, or genomes, of the famed fugu (or pufferfish) and elephant shark, has joined The Genome 10K Project, an international effort to build an invaluable repository of DNA sequences on 10,000 species of animals for conducting comparative studies on a scale that currently can not be achieved.

A painstaking analysis of thousands of genes and the proteins they encode shows that human beings are biologically complex, at least in part, because of the way humans evolved to cope with redundancies arising from duplicate genes.

A global collaborative has produced a first draft of the genome of a domesticated pig, an achievement that will lead to insights in agriculture, medicine, conservation and evolution.

In a dramatic illustration of the power of emerging genetic technologies, Yale University researchers have reported making a clinical diagnosis for the first time using comprehensive DNA sequencing of all the protein-coding genes in the genome. The information changed the course of treatment of a baby boy suffering from symptoms of dehydration thousands of miles away in Turkey.

Today sees the launch of Ensembl Plants – a freely available web resource for plant genomics research – by the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), in partnership with the Cold Spring Harbor Laboratory, USA. Ensembl Plants allows researchers worldwide to access and visualise the results of genome-scale experiments in different plant species. By pinpointing the genetic basis of beneficial characteristics such as drought and pest resistance, Ensembl Plants will make it easier for scientists to improve the productivity and health of crops - an important step towards meeting growing global food requirements over the coming decade.

The first ever genetic linkage map for a non-avian member of the Class Reptilia has been developed. Researchers writing in the open access journal BMC Genomics have constructed a first-generation genetic linkage map for the saltwater crocodile Crocodylus porosus.

Emory researchers are tapping the latest-generation DNA sequencing technology to become the first explorers of the genomics of agricultural ant societies.

Today, researchers at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) launch a new database, the Gene Expression Atlas, which allows scientists to search and compare gene expression data at unprecedented detail and scope. Observing how gene expression varies in different cell types, tissues and under disease conditions can help researchers understand gene function and to develop new drugs and therapies.

Agricultural Research Service (ARS) scientists have sequenced the genome of a parasite that can kill honey bees. Nosema ceranae is one of many pathogens suspected of contributing to the current bee population decline, termed colony collapse disorder (CCD). Researchers describe the parasite's genome in a study published June 5 in the open-access journal PLoS Pathogens.

Using a new technique for cDNA preparation combined with the latest sequencing methods, researchers have uncovered the larval transcriptome of a reef-building coral (Acropora millepora). Their study, described in the open access journal BMC Genomics, features the most extensive database of genes and genetic markers currently available for any coral.

A nearly complete collection of genes for a species of reef-building coral has been assembled by a team led by biologists from The University of Texas at Austin.

BGI-Shenzhen, in association with several other research institutes, announced today the launch of three new genome projects that focus on animals living in extreme environments. The three selected genomes are those of two polar animals: the polar bear and emperor penguin, and one altiplano animal: the Tibetan antelope.

Ground breaking findings by an international consortium of scientists who sequenced and analysed the bovine genome, could result in more sustainable food production.

Parents and school nurses take note. Lice are a familiar nuisance around the world and vectors of serious diseases, such as epidemic typhus, in developing regions. New research indicates that lice may actually be quite unique in the animal world. In a study published online in Genome Research (www.genome.org), scientists have analyzed the mitochondrial genome of the human body louse and discovered that it is fragmented into many pieces – a remarkable finding in animals that will surely spark discussion about how it evolved and what advantages it might confer.

Modern genotyping technologies offer new opportunities to explore how genes influence health and disease, but also present the challenge of analyzing huge amounts of genetic and clinical data. With this in mind, investigators at the Lausanne Branch of the international Ludwig Institute for Cancer Research (LICR), the Swiss Institute of Bioinformatics (SIB) and the University Hospital of Lausanne have developed AssociationViewer, a computational tool that displays genetic differences between individuals on a large scale. Presented in the March 1st (Vol. 25/5) issue of Bioinformatics, the software is a public resource that will help scientists and physicians discover new genetic markers for diseases and other conditions.

The Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, and the 454 Life Sciences Corporation, in Branford, Connecticut, will announce on 12 February during the 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS) and at a simultaneous European press briefing that they have completed a first draft version of the Neandertal genome.

In a paper published in the journal Nature this week, Rutgers researchers Joachim Messing, Rémy Bruggmann, and a team of international collaborators have described the genome of sorghum, a drought-tolerant African grass. The findings could one day help researchers to produce better food crops for arid regions with rapidly expanding human populations, such as West Africa.

José Luis Lavín Trueba, a graduate in biology and biochemistry from the University of Salamanca (Spain) and currently collaborator in the Genetic and Microbiology Research Group at the Public University of Navarre, has enhanced the use of bioinformatic tools for the identification and annotation of certain fungal and bacterial genes.

A potent combination of powerful new analysis methods and abundant data from genomics projects is carrying microbiology forward into a new era. Bacteria in particular are shedding light on fundamental molecular and signalling processes of interest not just within microbiology, but across the whole spectrum of life sciences embracing higher organisms, including plants and vertebrates. Medical research will benefit through improved knowledge of how bacteria behave when inside host organisms such as humans, both in benevolent symbiotic relationships and when causing infectious diseases such as TB.

An international consortium‡ of researchers has begun an effort to sequence the genome of the domesticated turkey, Meleagris gallopavo. The genome sequence will be obtained using the Roche GS-FLX™ sequencing platform and the recently launched Roche GS FLX Titanium PicoTiterPlate device and reagents.

Scientists at Penn State are leaders of a team that is the first to report the genome-wide sequence of an extinct animal, according to Webb Miller, professor of biology and of computer science and engineering and one of the project's two leaders. The scientists sequenced the genome of the woolly mammoth, an extinct species of elephant that was adapted to living in the cold environment of the northern hemisphere. They sequenced four billion DNA bases using next-generation DNA-sequencing instruments and a novel approach that reads ancient DNA highly efficiently.

Australian researchers will today launch the world first detailed map of the kangaroo genome, completing the first phase of the kangaroo genomics project.

Increased use of computers to create predictive models of human disease is likely following a workshop organised by the European Science Foundation (ESF), which urged for a collaborative effort between specialists in the field. Human disease research produces an enormous amount of data from different sources such as animal models, high throughput genetic screening of human tissue, and in vitro laboratory experiments. This data operates at different levels and scales including genes, molecules, cells, tissues and whole organs, embodying a huge amount of potentially valuable insight that current computer modelling approaches often fail to exploit properly.

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