Viruses are masters of deception, duping their host's cells into helping them grow and spread. A new study has found that human cytomegalovirus (HCMV) can mimic a common regulatory protein to hijack normal cell growth machinery, disrupting a cell's primary anti-cancer mechanism.

When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by “silencing” unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise “targeting” of unwanted genes, such as those from the HIV virus.

A University of Leicester researcher has discovered how a protein in the blood – linked to defence against meningitis - plays a more vital role than previously understood in the body’s immune defence system.

University of Texas Medical Branch at Galveston researchers have achieved promising results with a potential new weapon against respiratory syncytial virus, the most common cause of infant hospitalization in the United States.

Fungi may have an important role to play in the fate of potentially dangerous depleted uranium left in the environment after recent war campaigns, according to a new report in the May 6th issue of Current Biology, a publication of Cell Press.

Bacteria that cause the bubonic plague may be more virulent than their close relatives because of a single genetic mutation, according to research published in the May issue of the journal Microbiology.

Influenza is currently a grave concern for governments and health organisations around the world. The worry is the potential for highly virulent bird flu strains, such as H5N1, to develop the ability to infect humans easily. New drugs and vaccines to halt the spread of the virus are badly needed. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the European Molecular Biology Laboratory (EMBL) and the joint Unit of Virus Host-Cell Interaction of EMBL, the University Joseph Fourier and National Centre for Scientific Research (CNRS), in Grenoble, France. In the current issue of Nature Structural and Molecular Biology they publish a high-resolution image of a key protein domain whose function is to allow the virus to multiply by hijacking the host cell protein production machinery. The findings open the way for the design of new drugs to combat future influenza pandemics.

Using classroom, hands-on activities can help instructors to communicate difficult scientific concepts and stimulate student thinking. Despite its importance, the diversity in soil microbes can conceptually be difficult to teach, especially in natural resource classrooms composed primarily of undergraduates who have had little exposure to microbiology. That's where the candy comes into play.

Researchers at the University of Illinois at Chicago have discovered how some bacteria can survive antibiotic treatment by turning on resistance mechanisms when exposed to the drugs. The findings, published in the April 24 issue of the journal Molecular Cell, could lead to more effective antibiotics to treat a variety of infections.

University of Iowa researchers have succeeded in wiping out established biofilms of Staphylococcus aureus (staph) by hijacking one of the bacteria's own regulatory systems. Although the discovery is not ready for clinical application, the findings offer insight into a dispersal mechanism for staph biofilms and might help identify therapeutic targets.

British and Canadian scientists expect to begin trials next month (May) to find out whether microbes can unlock the vast amount of energy trapped in the world's unrecoverable heavy oil deposits.

Researchers at Washington University in St. Louis have gained the first detailed insight into the way circadian rhythms govern global gene expression in Cyanothece, a type of cyanobacterium (blue-green alga) known to cycle between photosynthesis during the day and nitrogen fixation at night.

New research suggests that not everyone who is bitten by a malaria-infected mosquito develops life threatening health problems according to scientists at the University of Toronto.

Duke University researchers have made a major advance in understanding how bacteria divide. This could lead to new antibiotic treatments that prevent dangerous bacteria from multiplying.

Each winter, strains of influenza A virus infect North Americans, causing an average of 36,000 deaths. Now, researchers say the virus comes from a viral reservoir somewhere in the tropics, settling a key debate on the source of each season's infection.

Seasonal influenza strains constantly evolve in overlapping epidemics in Asia and sweep the rest of the world each year, an international research team has found.

Salmonella are wily and obnoxious bacterial invaders--escape artists capable of evading multiple immune responses and causing a harsh and debilitating intestinal infection.

Do influenza viruses persist in low levels year-round in the northern and southern hemispheres, or does a new crop of the virus emerge afresh in tropical zones such as Southeast Asia before spreading into temperate regions around the globe" Researchers have provided an answer to this long-standing question: new strains arise each year.

An investigation of the genes that govern spore formation in the bacteria B. subtilis shows that chance plays a significant role in determining which of the microbes sacrifice themselves for the colony and which go on to form spores.

An international group of American and Turkish research scientists, led by Sea Lane Biotechnologies, has created the first comprehensive monoclonal antibody libraries against avian influenza (H5N1) using samples from survivors of the 2005/2006 "bird flu" outbreak in Turkey. These antibody libraries hold the promise for developing a therapy that could stop a pandemic in its tracks and provide treatment to those infected, as well as potentially pointing the way towards the development of a universal flu vaccine. The expanded treatment and containment options offered by Sea Lane’s antibody libraries could help provide healthcare officials, researchers, and governments with unprecedented resources to combat this serious global health threat.

Cornell researchers have identified a mating mechanism that possibly could be adapted to prevent female mosquitoes from spreading the viruses that cause dengue fever, second only to malaria as the most virulent mosquito-borne disease in the tropical world.

Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so – that a group of cells important in controlling the disease are triggered to ‘commit suicide’ in patients who are chronically infected. This discovery provides an important new focus for developing therapies or vaccines that boost the body’s ability to manage this infection.

Researchers are finding out which bugs grow in intensive care units to develop a novel sampling regime that would indicate the threat of MRSA and other superbugs in the environment, scientists heard today (Monday 31 March 2008) at the Society for General Microbiology’s 162nd meeting being held this week at the Edinburgh International Conference Centre.

One of the world’s deadliest diseases, caused by the Ebola virus, may finally be preventable thanks to US and Canadian researchers, who have successfully tested several Ebola vaccines in primates and are now looking to adapt them for human use.

Scientists from The Forsyth Institute and King’s College, London have released a new tool for the research community, the Human Oral Microbiome Database, which provides descriptions of the approximately 600 microbes (bacteria) that are most commonly found in people’s mouths. Most bacteria living in the mouth are thought to be important for maintaining the health of teeth and gums, as well as for general human health. A smaller number are potentially disease causing. The database, which can be found at www.homd.org, will help scientists studying the role of specific microbes in human health and disease.

Researchers at the University of Washington have uncovered how the bacterium Staphylococcus aureus, including the notorious MRSA (methicillin-resistant Staph aureus) “superbug” strains, resists our body's natural defenses against infection. The work, which was featured on the cover of the March 21 issue of Science, could lead to new ways to fight the bacteria.

Michigan State University scientist Ned Walker is taking on one of the biggest killers in the world—malaria. And he believes he can help win the battle to save lives, especially the lives of children.

To develop new strategies to control tuberculosis (TB), a contagious disease that infects one-third of the world’s population and kills almost two million people every year, the University of Pittsburgh Center for Vaccine Research has received an $11.4 million grant from the Bill & Melinda Gates Foundation. The grant will enable Pitt researchers to use new imaging technologies to study TB to shorten and simplify its course of treatment, potentially improving survival and curtailing the global TB epidemic.

Using the Canadian Light Source synchrotron, an international team led by University of Calgary researcher Ken Ng has determined the detailed structure of the enzyme the Norwalk virus uses to make copies of its genetic code in order to replicate itself. The information is crucial to developing drugs that could be used to treat outbreaks of Norwalk and other related viruses.

Scientists at MIT have come up with a mathematical approach for analyzing a protein simultaneously in a set of ecologically distinct species to identify occurrences of natural selection in an organism’s evolution.