A filament-shaped artificial virus is formed by using a preorganized supramolecular nanoribbon as a template. The artificial virus, which is composed of the nanoribbon, small interfering RNAs (blue, double-helix shape), and hydrophobic guests (red), is highly efficient in delivering genes and drugs to the inside of cells. Credit: (C) Wiley-VCH 2008 Viruses are true experts at importing genetic material into the cells of an infected organism. This trait is now being exploited for gene therapy, in which genes are brought into the cells of a patient to treat genetic diseases or genetic defects. Korean researchers have now made an artificial virus. As described in the journal Angewandte Chemie, they have been able to use it to transport both genes and drugs into the interior of cancer cells.

Blocking a common immune system response cleared up plaques associated with Alzheimer’s Disease and enabled treated mice to recover some lost memory, Yale University researchers report Friday in the journal Nature Medicine.

Golf can be a good investment for the health, according to a new study from the Swedish medical university Karolinska Institutet. The death rate for golfers is 40 per cent lower than for other people of the same sex, age and socioeconomic status, which correspond to a 5 year increase in life expectancy. Golfers with a low handicap are the safest.

A laboratory culture of the bdelloid rotifer Adineta vaga. Rotifers may be able to incorporate DNA from other species into their genomes during the desiccation and rehydration phases of their life cycle. Credit: Eugene Gladyshev Where do you get your genes? If you are an animal, you inherit them from your parents at the moment of conception, and that's about it. No later incorporation of environmental DNA for you, unless you become host to a parasite or an endosymbiont that somehow transfers bits of its genome into yours (which is a rarely documented event).

In 1999, when Dr. Huda Zoghbi and her Baylor College of Medicine colleagues identified a mutation of the gene MeCP2 as the culprit in Rett syndrome, a neurodevelopmental disorder, the discovery was only the prelude to understanding a symphony of neurological missteps.

Somewhere in the murky past, between four and seven million years ago, a hungry common ancestor of today’s primates, including humans, did something novel. While temporarily standing on its rear feet to reach a piece of fruit, this protohominid spotted another juicy morsel in a nearby shrub and began shuffling toward it instead of dropping on all fours, crawling to the shrub and standing again.

In this week’s issue of Science, a team of researchers from the United States and Sweden report on a newly identified factor that controls the natural input of new nitrogen into boreal forest ecosystems. Nitrogen is the primary nutrient that dictates productivity (and thus carbon consumption) in boreal forests. In pristine boreal ecosystems, most new nitrogen enters the forest through cyanobacteria living on the shoots of feather mosses, which grows in dense cushions on the forest floor. These bacteria convert nitrogen from the atmosphere to a form that can be used by other living organisms, a process referred to as “nitrogen-fixation.” The researchers showed that this natural fertilization process appears to be partially controlled by trees and shrubs that sit above the feather mosses.

Long viewed as straitlaced spinsters, sexless freshwater invertebrate animals known as bdelloid rotifers may actually be far more promiscuous than anyone had imagined: Scientists at Harvard University have found that the genomes of these common creatures are chock-full of DNA from plants, fungi, bacteria, and animals.

A new HIV data browser developed by the University of California, Santa Cruz, and the nonprofit organization Global Solutions for Infectious Diseases (GSID) will give researchers access to a wealth of data collected during clinical trials of an AIDS vaccine. Although the vaccine did not succeed in preventing infections, the clinical trial generated a huge amount of valuable data for researchers studying how the virus evolves and causes new infections.

By studying heat-loving microbes, two research teams have gained new insight into how seemingly small differences in a single protein involved in DNA transcription and repair can lead to strikingly different genetic disorders in humans.

In Germany alone, about three million – mostly elderly – patients suffer from poorly healing large-area wounds caused by complaints such as diabetes, burns or bedsores. The wounds can be treated with conventional collagen dressings or polylactic acid dressings, but the success rate is not as good as it should be.

The common fruit fly circling your week-old peach has helped scientists zero in on a protein critical to the insect's eggshell formation.

The protein MAEBL is critical for completing the life cycle of malaria parasites in mosquitoes, allowing the insects to transmit the potentially deadly infection to humans, a University of South Florida study has shown. The research may ultimately help provide a way to better control malaria by blocking development of the malaria parasite in the mosquito.

Scientists search for drug candidates in some very unlikely places. Not only do they churn out synthetic compounds in industrial-scale laboratories, but they also scour coral reefs and scrape tree bark in the hope of stumbling upon an unsuspecting molecule that just might turn into next year’s big block buster. But one region that scientists have not been searching is their guts. Literally.

A monkey has successfully fed itself with fluid, well-controlled movements of a human-like robotic arm by using only signals from its brain, researchers from the University of Pittsburgh School of Medicine report in the journal Nature. This significant advance could benefit development of prosthetics for people with spinal cord injuries and those with “locked-in” conditions such as Lou Gehrig’s disease, or amyotrophic lateral sclerosis.

An Iowa State University researcher has found that sick female deer mice devote their energy to producing healthier offspring.

A study released today reveals a cellular mechanism involved in alcohol dependence. The study, in the May 28 issue of The Journal of Neuroscience, shows that gabapentin, a drug used to treat chronic pain and epilepsy, reduces alcohol intake in alcohol-dependent rats by normalizing chemical communication between neurons, which is altered by chronic alcohol abuse.

You went to a wedding yesterday. The service was beautiful, the food and drink flowed and there was dancing all night. But people tell you that you are in hospital, that you have been in hospital for weeks, and that you didn’t go to a wedding yesterday at all.

Researchers at The University of Nottingham have taken some important first steps to creating a synthetic copycat of a living cell, a leading science journal reports.

Researchers from the John Innes Centre and the University of East Anglia have recently elucidated the structure and function of an enzyme which is involved in decorating antibiotics with sugar molecules. Many antibiotics have a variety of different carbohydrate molecules attached to them which can help the antibiotic to be taken up by the target organism or overcome resistance. By manipulating the sugar, it may be possible to restore usefulness in antibiotics to which resistance has developed.

Rocks made of basalt on and under the ocean bottom harbor surprising numbers of deep-sea bacteria. Seafloor bacteria on ocean-bottom rocks are more abundant and diverse than previously thought, appearing to "feed" on the planet's oceanic crust, according to results of a study reported in this week's issue of the journal Nature.

The Butterfly bush was introduced to Europe about one hundred years ago from China and has been cultivated since then. Invasive plant species can flourish better in their new homes than in their place of origin. The reasons for this can be genetic changes or the lack of herbivores such as insects that first have to adapt to the newcomers. These are the conclusions of researchers from the Helmholtz Centre for Environmental Research (UFZ) from their research on Buddleia or the Butterfly bush (Buddleja davidii) and Oregon grape (Mahonia aquifolium). Due to this, invasive plant species would have an advantage over other native plant species and could therefore pose a threat to the ecological balance, as researchers have written in the scientific journal Diversity and Distributions.

Geneticists of Leiden University Medical Centre (LUMC) are the first to determine the DNA sequence of a woman. She is also the first European whose DNA sequence has been determined. This has been announced by the researchers this morning, during a special press conference at ‘Bessensap’, a yearly meeting of scientists and the press in the Netherlands.

Scientists at the Swedish medical university Karolinska Institutet have developed a new DNA-sequencing method that is much cheaper than those currently in use in laboratories. They hope that this new method will make it possible to map disease genes in large patient groups, which in turn can mean quicker breakthroughs for new treatments for a wide variety of diseases.

What causes tropical life to thrive: temperature, or sunlight?

The first large-scale analysis of proteins in the brains of monkeys addicted to cocaine reveals new information on how long-term cocaine use changes the amount and activity of various proteins affecting brain function.

A pair of Los Alamos National Laboratory theorists have developed a mathematical tool that could help health experts and crisis managers determine in real time whether an emerging infectious disease such as avian influenza H5N1 is poised to spread globally.

Both lignin and cellulose are found in the rigid cell walls of the xylem cells (those that conduct water) in the primitive plant, Selaginella. Biologists have discovered that a fundamental building block in the cells of flowering plants evolved independently, yet almost identically, on a separate branch of the evolutionary tree--in an ancient plant group called lycophytes that originated at least 420 million years ago.

Is the smell of almonds closer to that of roses or bananas? Weizmann Institute scientists have now answered that question (roses) by showing for the first time that smells can be mapped and the relative distance between various odors determined. Their findings, which appeared recently in Nature Methods, may help scientists to unravel the basic laws underlying our sense of smell, as well as potentially enabling odors to be digitized and transferred via computer in the future.

A new study into the potential health hazards of the revolutionary nano-sized particles known as ‘buckyballs’ predicts that the molecules are easily absorbed into animal cells, providing a possible explanation for how the molecules could be toxic to humans and other organisms.

For people with diabetes, sipping a mug of steaming, flavorful cocoa may seem a guilty pleasure. But new research suggests that indulging a craving for cocoa can actually help blood vessels to function better and might soon be considered part of a healthy diet for the prevention of cardiovascular disease.

When a young gene known as sphinx is inactivated in the common fruit fly, it leads to increased male-male courtship, scientists report in the May 27, 2008, issue of the Proceedings of the National Academy of Sciences.

By identifying a protein that restricts the release of HIV-1 virus from human cells, scientists believe they may be closer to identifying new approaches to treatment. The research is published in the advance online edition of Nature Medicine.

A mapmaker and a mathematician may seem like an unlikely duo, but together they worked out a way to measure longitude – and kept millions of sailors from getting lost at sea. Now, another unlikely duo, a virologist and a biophysicist at Rockefeller University, is making history of their own. By using a specialized microscope that only illuminates the cell’s surface, they have become the first to see, in real time and in plain view, hundreds of thousands of molecules coming together in a living cell to form a single particle of the virus that has, in less than 25 years, claimed more than 25 million lives: HIV.

With improved resolution, tissue-specific molecular markers and precise timing, University of Oregon biologist James A. Weston and colleagues have possibly overturned a long-standing assumption about the origin of embryonic cells that give rise to connective and skeletal tissues that form the base of the skull and facial structures in back-boned creatures from fish to humans.

Researchers at North Carolina State University have discovered that adding tiny bits of gold to a failed HIV drug rekindle the drug’s ability to stop the virus from invading the body’s immune system.

Honeybees pollinate our crops and produce the honey we enjoy. We all know that. What we are perhaps not aware of, however, is just how or why they do this and why we are so dependent on what they do.

The International Institute for Species Exploration at Arizona State University and an international committee of taxonomists – scientists responsible for species exploration and classification – today announce the top 10 new species described in 2007.

Diabetes researchers at the John G. Rangos Sr. Research Center at Children’s Hospital of Pittsburgh of UPMC have identified a potential target for the development of new therapies to treat hypertriglyceridemia, a lipid disorder commonly seen in people who are obese and diabetic. Results of their study are published in the June issue of the Journal of Clinical Investigation.

Sea buckthorn (Hippophae rhamnoides) berries are well known for their cholesterol busting properties, but scientists in India say that its leaves are also rich in anti-oxidants and may help ward off liver disease, according to new research due to be published in the Society of Chemical Industry’s (SCI) Journal of the Science of Food and Agriculture.