Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Förstemann of the Gene Center of Ludwig-Maximilians-Universität (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Förstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)

The human eye lens consists of a highly concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective function fails, the lens blurs and the patient develops cataracts. Two research groups at the Department of Chemistry of the Technische Universitaet Muenchen (TUM) have succeeded in explaining the molecular architecture of this kind of protective protein. Their findings, which are published online in the current early edition of PNAS (Proceedings of the National Academy of Sciences), shed new light on the work of these proteins and may be able to help in the development of new treatments.

You probably hadn't noticed -- but the head shape and overall size of rodents has been changing over the past century. A University of Illinois at Chicago ecologist has tied these changes to human population density and climate change.

Researchers at the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health are working with Argentina's National Institute of Infectious Diseases, the National Administration of Laboratories and Health Institutes (ANLIS), and Roche 454 Life Sciences to decode the complete genomic sequences of influenza pandemic (H1N1) 2009 virus from patients with severe respiratory disease. The scientists will be comparing sequences of viruses associated with the current outbreak in Argentina with those found in other locations to determine if there are differences that may be linked to higher mortality rates or provide insights into virus evolution.

Scientists from Scotland and Singapore have unraveled a mystery that has perplexed scientists since red wine was first discovered to have health benefits: how does resveratrol control inflammation? New research published in the August 2009 print issue of The FASEB Journal (http://www.fasebj.org), not only explains resveratrol's one-two punch on inflammation, but also show how it—or a derivative—can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.

A virus discovered last year in a rare form of skin cancer has also been found in people with the second most common form of skin cancer among Americans, according to researchers at the Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.

The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.

An international team of scientists with divergent views on ocean ecosystems has found that efforts to rebuild many of the world's fisheries are worthwhile and starting to pay off in many places around the world. Their study puts into perspective recent reports predicting a total collapse of global fisheries within 40 years.

A new analysis of the remains of a Tyrannosaurus rex (T. rex) that roamed Earth 68 million years ago has confirmed traces of protein from blood and bone, tendons, or cartilage. The findings, scheduled for publication in the Sept. 4 issue of ACS' monthly Journal of Proteome Research, is the latest addition to an ongoing controversy over which biochemical remnants can be detected in the dino.

A bizarre New Zealand bat that is as much at home walking four-legged on the ground as winging through the air had an Australian ancestor 20 million years ago with the same rare ability, a new study has found.

A research team comprised of faculty at Worcester Polytechnic Institute's (WPI) Life Sciences and Bioengineering Center (LSBC) and investigators at CellThera, a private company also located at the LSBC, has discovered a novel way to turn on stem cell genes in human fibroblasts (skin cells) without the risks associated with inserting extra genes or using viruses. This discovery opens a new avenue for reprogramming cells that could eventually lead to treatments for a range of human diseases and traumatic injuries by coaxing a patient's own cells to repair and regenerate the damaged tissues.

Large trees have declined in Yosemite National Park during the 20th century, and warmer climate conditions may play a role.

Recycling is a critical component in the process of transmitting information from one neuron to the next, and a large protein called Tweek plays a critical role, said an international consortium of researchers led by Baylor College of Medicine (www.bcm.edu) in a report in the current issue of the journal Neuron.

An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease. The therapy has been shown to restore lost vision in animal models of retinitis pigmentosa (RP). Their work is being funded in part by a $1.5 million grant from the Prince Salman Center for Disability Research in Saudi Arabia, where the recessive gene mutation that leads to the eye disease RP has been found in children from several families.

The ocean's smallest swimming animals, such as jellyfish, can have a huge impact on large-scale ocean mixing, researchers have discovered.

For the first time in nearly 50 years, a population of a nearly extinct frog has been rediscovered in the San Bernardino National Forest's San Jacinto Wilderness. Biologists from the U.S. Geological Survey (USGS) assessing suitability of sites to re-establish frogs and scientists from the San Diego Natural History Museum retracing a 1908 natural history expedition both rediscovered the rare mountain yellow-legged frog in the San Jacinto Wilderness near Idyllwild, Calif.

The mechanism used by 'Natural Killer' immune cells in the human body to distinguish between diseased cells, which they are meant to destroy, and normal cells, which they are meant to leave alone, is revealed in new detail in research published today (Tuesday 28 July) in PLoS Biology.

Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry.

An international team of scientists has discovered an extinct rodent species, based on fossil tooth remains found in Alborache, Valencia. Eomyops noeliae, from the Eomyidae family, represents the oldest find within this genus in the world.

Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research, a journal of the American Association for Cancer Research, illustrates how the technique may answer questions about Herceptin resistance.

Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year.

The first ever genetic linkage map for a non-avian member of the Class Reptilia has been developed. Researchers writing in the open access journal BMC Genomics have constructed a first-generation genetic linkage map for the saltwater crocodile Crocodylus porosus.

Hungry, sexual organisms replaced well-fed, clonal organisms in the Caribbean Sea as the Isthmus of Panama arose, separating the Caribbean from the Pacific, report researchers from the Smithsonian Tropical Research Institute and Scripps Institution of Oceanography. The fossil record shows that if a species could shift from clonal to sexual reproduction it survived. Otherwise it was destined for extinction, millions of years later.

A new urine test developed with funding from the Wellcome Trust will allow doctors to diagnose Chlamydia infection in men within the hour, improving the ability to successfully treat the infection on the spot and prevent re-transmission.

Bacterial infection is a major health threat to patients with severe burns and other kinds of serious wounds such as traumatic bone fractures. Recent studies have identified an important new weapon for fighting infection and healing wounds: insulin.

The cytokine IL-9 promotes a multiple sclerosis-like disease in mice, according to a new study by Nowak et al. published online on July 13th in the Journal of Experimental Medicine. In a related Commentary, Richard Locksley discusses the molecular and genetic regulation of cytokine production by CD4+ T helper (Th) cells and the plasticity among different Th subsets. The Commentary will be published online in the Journal of Experimental Medicine on Monday, July 27th.

Not satisfied with simply thwarting its host's defensive maneuvers, HIV actually twists one to its advantage, based on new findings from Kyei et al. in the July 27, 2009 issue of the Journal of Cell Biology (www.jcb.org). Vojo Deretic and colleagues suggest that autophagy—a stress response process—helps HIV to proliferate and that conversely, blocking autophagy lessens HIV production.

Switching off a key DNA repair system in the developing nervous system is linked to smaller brain size as well as problems in brain structures vital to movement, memory and emotion, according to new research led by St. Jude Children's Research Hospital scientists.

The first ever overall nation-wide estimate of the tiger population brought a positive ray of hope among conservationists. The figures announced by the Nepal Government's Department of National Parks and Wildlife Conservation (DNPWC) shows the presence of 121 (100 – 194) breeding tigers in the wild within the four protected areas of Nepal. The 2008 tiger population estimate was jointly implemented by the DNPWC, Department of Forests (DOF), WWF, National Trust for Nature Conservation (NTNC) with support from Save The Tiger Fund (STF), WWF-US, WWF-UK, WWF International and US Fish and Wildlife Service (USFWS).

Movement through a complex meshwork of small branches at the heights of tropical forests presents a unique challenge to animals wanting to forage for food safely. It can be particularly dangerous for large animals where a fall of up to 30m could be fatal. Scientists found that dangerous tree vibrations can be countered by the orang-utan's ability to move with an irregular rhythm.

Two University of British Columbia researchers are part of an international team recommending standards for the DNA barcoding of land plants, a step they hope will lead to a universal system for identifying over 400,000 species, and ultimately boost conservation efforts.

Evidence buried in the chromosomes of animals and plants strongly suggests only one group -- mammals -- have seen their genomes shrink after the dinosaurs' extinction. What's more, that trend continues today, say Indiana University Bloomington scientists in the first issue of a new journal, Genome Biology and Evolution.

Researchers in Israel and Kenya have shown that the contribution of variable degrees of immune suppression, either due to existing chronic infections such as parasitemias and/or nutrition, in different populations may influence and prolong the serological-diagnostic window period of HIV. However, the immunosuppression can be overcome, by in-vitro enhancement of antibody production (termed- Stimmunology). The results, which appear in the August 2009 issue of Experimental Biology and Medicine, show that pre-treating the whole blood sample in the SMARTube™ containing immune potentiating agents promoted the synthesis and release of antibodies against HIV-1 prior to their detection in corresponding plasma samples in a group of donors who would otherwise be classified as HIV-1 seronegative blood donors. The identification of techniques that can lead to detection of HIV infection during this window period is of obvious public health importance especially in resource poor settings highlighting the importance of these findings. Overcoming the suppression, in-vitro, led to the production of detectable levels of anti-HIV antibodies in the whole blood sample and to the detection of potentially infectious blood units which were missed by regular HIV serology. Interestingly, the ratio of missed infections among the total HIV infected blood donors was higher among the younger (high-school) donors versus adult donors.

Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. The study was published in the journal Cancer Research on June 15.

Acoustic tags and numerical river models are two technologies developed by researchers at the Department of Energy's Pacific Northwest National Laboratory that are helping improve salmon passage at the Columbia Basin's hydroelectric dams.

The same mechanism that helps you detect bad-tasting and potentially poisonous foods may also play a role in protecting your airway from harmful substances, according to a study by scientists at the University of Iowa Roy J. and Lucille A. Carver College of Medicine. The findings could help explain why injured lungs are susceptible to further damage.

Researchers appear to have a new way to fix a broken heart. They have devised a method to coax heart muscle cells into reentering the cell cycle, allowing the differentiated adult cells to divide and regenerate healthy heart tissue after a heart attack, according to studies in mice and rats reported in the July 24th issue of the journal Cell, a Cell Press publication. The key ingredient is a growth factor known as neuregulin1 (NRG1 for short), and the researchers suggest that the factor might one day be used to treat failing human hearts.

"If you could read my mind, love, what a tale my thoughts could tell" —Gordon Lightfoot

Psychopharmaceutical use has risen over recent years. This is fact, but what is not clear is the reason why. Researchers from four Madrid-based health centres have shown that family conflict is not a significant factor. However, the results published in the journal Atención Primaria are striking: in Spain, 24% of women take antidepressants and more than 30% take tranquillisers.

Thomas Marler recently published the results of his research that reveal some of the attributes of the long-lived leaves of Guam's Cycas micronesica plants. "These leaves are relatively large and are constructed of tough tissues," said Marler. "Both of these factors indicate the construction costs of this leaf form are substantial."