Researchers have built a computer model of the crowded interior of a bacterial cell that – in a test of its response to sugar in its environment – accurately simulates the behavior of living cells.

Two U.S. Department of Agriculture (USDA) scientists may have discovered "the map to El Dorado" for the American elm-a previously hidden population of elms that carry genes for resistance to Dutch elm disease. The disease kills individual branches and eventually the entire tree within one to several years.

The most recently discovered amino acid, pyrrolysine, is produced by a series of just three chemical reactions with a single precursor – the amino acid lysine, according to new research.

New Delhi, India – The Indian Government today released new tiger population numbers for the first time since 2007, indicating that numbers have increased in the country that has half of the world's remaining wild tigers.

By combining sophisticated mathematical techniques more commonly used by spies instead of scientists with the power and versatility of functional magnetic resonance imaging (fMRI), a Penn neurologist has developed a new approach for studying the inner workings of the brain. A hidden pattern is encoded in the seemingly random order of things presented to a human subject, which the brain reveals when observed with fMRI. The research is published in the journal NeuroImage.

For the first time, a virus that causes respiratory disease in humans has been linked to the deaths of wild mountain gorillas, reports a team of researchers in the United States and Africa.

Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

There are billions of neurons in the brain and at any given time tens of thousands of these neurons might be trying to send signals to one another. Much like a person trying to be heard by his friend across a crowded room, neurons must figure out the best way to get their message heard above the din.

The human immunodeficiency virus (HIV), the cause of AIDS, makes use of the base excision repair pathway when inserting its DNA into the host-cell genome, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Crippling the repair pathway prevents the virus from completing this critical step in the retrovirus's life cycle.

Demonstrating an important milestone for the longevity and utility of implanted brain-computer interfaces, a woman with tetraplegia using the investigational BrainGate* system continued to control a computer cursor accurately through neural activity alone more than 1,000 days after receiving the BrainGate implant, according to a team of physicians, scientists, and engineers developing and testing the technology at Brown University, the Providence VA Medical Center, and Massachusetts General Hospital (MGH). Results from five consecutive days of device use surrounding her 1,000th day in the device trial appeared online March 24 in the Journal of Neural Engineering.

Philadelphia, PA, March 23, 2011 – Although acupuncture is commonly used for pain control, doubts about its effectiveness and safety remain. Investigators from the Universities of Exeter & Plymouth (Exeter, UK) and the Korea Institute of Oriental Medicine (Daejeon, South Korea) critically evaluated systematic reviews of acupuncture as a treatment of pain in order to explore this question. Reporting in the April 2011 issue of PAIN®, they conclude that numerous systematic reviews have generated little truly convincing evidence that acupuncture is effective in reducing pain, and serious adverse effects continue to be reported.

Research led by Daitoku Sakamuro, PhD, Assistant Professor of Pathology at LSU Health Sciences Center New Orleans and the LSUHSC Stanley S. Scott Cancer Center, has identified a protein that enables the activation of a DNA-repair enzyme that protects cancer cells from catastrophic damage caused by chemo and radiation therapy. This protein, called c-MYC oncoprotein, can initiate and promote almost all human cancers and discovering the role it plays in cancer treatment resistance may lead to advances that save lives. The work is published in the March 29, 2011 issue of Science Signaling, a publication of the American Association for the Advancement of Science. Although scientists have known that cancer cells can acquire resistance to DNA-damaging therapeutic agents, the genetic mechanisms through which this occurs have remained unclear until now.

Norovirus is the leading cause of acute gastroenteritis in the United States and is estimated to cause nearly 21 million cases annually. It is highly transmissible through person-to-person contact and contaminated food, water, and environmental surfaces. The results of an investigation of a 2009 outbreak on a cruise ship shed light on how the infections can spread and the steps both passengers and crew can take to prevent them. The findings are published in a new study in Clinical Infectious Diseases and available online (http://www.oxfordjournals.org/our_journals/cid/cir144.pdf).

Since their discovery in the 1990s, microRNAs have proven to play a complex role in normal and abnormal functioning of many organ systems. In the April issue of Translational Research, entitled "MicroRNAs: A Potential New Frontier for Medicine," an international group of medical experts explores several themes related to our current understanding of microRNAs and the role they may play in the future of medicine.

A team of researchers from the University of Montreal and McGill University have discovered a type of "cellular bilingualism" – a phenomenon that allows a single neuron to use two different methods of communication to exchange information. "Our work could facilitate the identification of mechanisms that disrupt the function of dopaminergic, serotonergic and cholinergic neurons in diseases such as schizophrenia, Parkinson's and depression," wrote Dr. Louis-Eric Trudeau of the University of Montreal's Department of Pharmacology and Dr. Salah El Mestikawy, a researcher at the Douglas Mental Health University Institute and professor at McGill's Department of Psychiatry. An overview of this discovery was published in the Nature Reviews Neuroscience journal.

DNA contains all of the genetic instructions that make us who we are, and maintaining the integrity of our DNA over the course of a lifetime is a critical, yet complex part of the aging process. In an important, albeit early step forward, scientists have discovered how DNA maintenance is regulated, opening the door to interventions that may enhance the body's natural preservation of genetic information.

University of Miami (UM) Rosenstiel School of Marine & Atmospheric Science scientist Chris Langdon and colleagues developed a new tool to monitor coral reef vital signs. By accurately measuring their biological pulse, scientists can better assess how climate change and other ecological threats impact coral reef health worldwide.

A multi-center gene therapy trial for patients with advanced Parkinson’s disease demonstrated reduced symptoms of the progressive movement disorder, according to a new study published in Lancet Neurology. The study was designed to deliver the gene for glumatic acid decarboxylase (GAD) packaged in inert viral vectors into an area of the brain called the subthalamic nucleus. GAD makes an important inhibitory chemical called GABA. The subthalamic nucleus is abnormally activated in Parkinson’s disease and this activity leads to the debilitating movement problems. The idea of the gene therapy is that the billions of AAV-2 GAD viral vectors delivered into the subthalamic nucleus will increase GABA, thereby quieting this brain region.

A new plant species is providing an insight into how evolution works and could help improve crop plants, scientists have revealed.

The common fig is a subtropical, deciduous fruit tree grown in most Mediterranean-type climates. Although some believe that figs may be the oldest cultivated fruit species on earth, global expansion of fig crops has been hindered by the narrow research base pertaining to production practices and the limited number of fig cultivars currently available. Recently, three black figs were established in the Mediterranean-type climate of Western Cape Province of South Africa to provide fruit for fresh markets throughout South Africa and Europe.

Biochemist Leor Weinberger and colleagues at the University of California, San Diego and UCLA have proposed a fundamentally new intervention for the HIV/AIDS epidemic based on engineered, virus-like particles that could subdue HIV infection within individual patients and spread to high-risk populations that are difficult for public health workers to reach.

When Geoffrey Murphy, Ph.D., talks about plastic structures, he's not talking about the same thing as Mr. McGuire in The Graduate. To Murphy, an associate professor of molecular and integrative physiology at the University of Michigan Medical School, plasticity refers to the brain's ability to change as we learn.

Improving land management and farming practices in Australia could have an effect on global climate change, according to a study published in the International Journal of Water.

It's a cloak that surpasses all others: a microscopic carbon cloak made of graphene that could change the way bacteria and other cells are imaged.

Enzymes are proteins that speed up chemical reactions, such as laundry detergent digesting protein stains, which are otherwise very difficult to remove. A research team led by Professor Kam-bo Wong of the Centre for Protein Science and Crystallography, School of Life Sciences at The Chinese University of Hong Kong demonstrated a fundamental principle in changing the activity of enzymes by means of protein engineering. The findings provide potential insights into the future design of biotechnologically important enzymes, and will be published in next week's issue of the online, open access journal PLoS Biology.

Sex and violence, or at least death, are the key to reproduction for the orchid Satyrium pumilum. Research led by Timotheüs van der Niet at the University of KwaZulu-Natal shows that the orchid lures flies into its flowers by mimicking the smell of rotting flesh. A new study comparing the scent of the orchids with that of roadkill is to be published in the Annals of Botany http://dx.doi.org10.1093/aob/mcr048 .

In the years since the AIDS epidemic began, it has become clear that there is substantial variation in the way that individuals respond to HIV infection. Although most progress quickly from initial infection to immunodeficiency, a small subset survive for long periods without developing symptoms. These patients, dubbed elite controllers, display undetectable levels of viral replication, but the mechanism that explains how their immune systems effectively control the virus is not understood.

The so-called cellular slime mold, a unicellular organism that may transition into a multicellular organism under stress, has just been found to have a tissue structure that was previously thought to exist only in more sophisticated animals. What's more, two proteins that are needed by the slime mold to form this structure are similar to those that perform the same function in more sophistical animals.

Preserving an intact population of weed-eating fish may be vital to saving the world's coral reefs from being engulfed by weed as human and climate impacts grow.

When Patricia Manrique was told she needed her gallbladder removed she immediately thought about the classroom full of children who rely on her to teach them tap and ballet each day. The Chicago Park District physical instructor needed a way to get the surgery performed without being laid up for weeks so she opted for an innovative minimally invasive procedure called Natural Orifice Translumenal Endoscopic Surgery (NOTES) that would allow surgeons to perform organ removal surgery without any visible incisions and have her back on her feet the same day. Northwestern Medicine physicians were among the first in the U.S. to perform several types of the procedure and are leading the charge in organ removal through the mouth or vagina.

Earth's biodiversity—the number of microorganisms, plants, and animals, their genes, and their ecosystems (such as rainforests and grasslands)—is declining at an alarming rate, even faster than the last mass extinction 65 million years ago. In fact, two thirds of the terrestrial species that exist today are estimated to be extinct by the end of this century. Humans are an integral part of this extensive network of life. We depend on biodiversity for goods and services; we impact biodiversity via rapidly expanding human population growth, consumption of resources, and spread of disease; and we study biodiversity in order to understand, conserve, and protect it.

Ten years ago, scientists seeking to understand how a certain type of feature on a cell called an L-type calcium channel worked created a knockout mouse missing both copies of the CACNA1D gene.

Hybrid plants with multiple genome copies show evidence of preferential treatment of the genes from one ancient parent over the genes of the other parent, even to the point where some of the unfavored genes eventually are deleted.

Researchers from Rice University and Georgia Institute of Technology have found support for the theory that the brain has three concentric layers of working memory where it stores readily available items. Memory researchers have long debated whether there are two or three layers and what the capacity and function of each layer is.

Although thousands of people commit suicide worldwide each year, researchers and doctors do not have any method for evaluating a person's likelihood of thinking about or trying to commit suicide. An international group of scientists, in which the Hospital del Mar Research Institute (IMIM) has participated, has devised the first risk index in order to prevent suicides.

In the fall of 1917, a new strain of influenza swirled around the globe. At first, it resembled a typical flu epidemic: Most deaths occurred among the elderly, while younger people recovered quickly. However, in the summer of 1918, a deadlier version of the same virus began spreading, with disastrous consequence. In total, the pandemic killed at least 50 million people — about 3 percent of the world's population at the time.

A breakthrough by scientists at The University of Nottingham could provide hope for any allergy sufferers who have ever had to choose between their health and their household pet.

Researchers at the University of Texas Southwestern Medical Center and the University of Texas at Dallas are reporting today at the 55th Annual Biophysical Society Annual Meeting in Baltimore, MD how they are using a novel 3D cell imaging method for studying the complex spatial-temporal dynamics of protein transport, providing a solution to this fundamental problem in cell biology.

Research suggests that intelligence in humans is controlled by the part of the brain known as the 'cortex', and most theories of age-related cognitive decline focus on cortical dysfunction. However, a new study of Scottish older adults, reported in the April 2011 issue of Elsevier's Cortex (http://www.sciencedirect.com/science/journal/00109452), suggests that grey matter volume in the 'cerebellum' at the back of the brain predicts cognitive ability, and keeping those cerebellar networks active may be the key to keeping cognitive decline at bay.

Researchers at the Instituto de Medicina Molecular in Lisbon, Portugal and the Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, are making major strides toward understanding the life cycle of flaviviruses, which include some of the most virulent human pathogens: yellow fever virus, Dengue virus, and the West Nile Virus, among others.