Members of a USC-led research team say they've made a big improvement in a new breed of electronic detectors for viruses and other biological materials — one that may be a valuable addition to the battle against epidemics.

Vancomycin resistant enterococci (VRE) have been found in sewage sludge, a by-product of waste-water treatment frequently used as a fertilizer. Researchers writing in the open access journal Acta Veterinaria Scandinavica point out the danger of antibiotic resistance genes passing into the human food chain.

By using ultrafast laser pulses to slice off pieces of chromosomes and observe how the chromosomes behave, biomedical engineers at the University of Michigan have gained pivotal insights into mitosis, the process of cell division.

Researchers have identified the locking mechanism that allows some neurons to form synapses to pass along essential information. Mutations of genes that produce a critical cell-adhesion molecule involved in the work were previously linked to autism.

Most polluted or damaged ecosystems worldwide can recover within a lifetime if societies commit to their cleanup or restoration, according to an analysis of 240 independent studies by researchers at the Yale School of Forestry & Environmental Studies. Their findings will appear in the June edition of the journal PLoS ONE.

Premature ejaculation can be embarrassing, but a new study suggests that it might be a genetic disorder.

Sulfolobus islandicus, a microbe that can live in boiling acid, is offering up its secrets to researchers hardy enough to capture it from the volcanic hot springs where it thrives. In a new study, researchers report that populations of S. islandicus are more diverse than previously thought, and that their diversity is driven largely by geographic isolation.

GAINESVILLE, Fla. — Focusing HIV drug development on immune cells called macrophages instead of traditionally targeted T cells could bring us closer to eradicating the disease, according to new research from University of Florida and five other institutions.

A research team led by a University of Iowa investigator has generated DNA-like compounds that effectively inhibit the cells responsible for systemic lupus erythematosus -- the most common and serious form of lupus. There currently is no cure for this chronic autoimmune condition that damages the skin, joints and internal organs and affects an estimated one million Americans.

In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.

If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations – the regions in which the immune response is organised. However, Prof. Burkhard Becher, University of Zurich, suggests in a new paper – published in this week's issue of PLoS Biology – that lymph nodes are not essential in the mouse in marshalling T-cells (a main immune foot soldier) to respond to a breach of the skin barrier. This result is both surprising in itself, and suggests a novel function for the liver as an alternate site for T-cell activation.

Even microbes are governed by the principle of supply and demand – at least at the genetic level. Not all of their gene products, the blueprints for proteins, are required at all times. That means most of their genes only become active when they are needed, as is the case in higher organisms. In the simplest case, a transcription factor will activate the gene in question at the right time. Genes that are regulated in a somewhat more complex manner, on the other hand, are kept inactive by a repressor that is removed only when the gene is needed. Which of these two regulation mechanisms will develop is a question of demand, along the lines of a "use-it-or-lose-it" principle: if genes are frequently active, then, as a rule, they will be directly induced. Genes that encode more rarely used proteins, on the other hand, tend to be kept inactive by repressors. LMU physicist Ulrich Gerland and Professor Terence Hwa of the University of California have now demonstrated using computer simulations and theoretical analyses that another – indeed opposing – principle also comes into play: "wear-and-tear". According to this principle, direct activation can lead to harmful changes. "Which of the two principles prevails depends on evolutionary criteria such as the population size and the periods over which environmental changes take place," says Gerland. "Our study may serve as a useful basis for more detailed studies of the evolution of regulatory systems." (PNAS Early Edition, 22 Mai 2009)

It appears that some superbugs have evolved to develop the ability to manipulate the immune system to everyone's advantage.

New light has been thrown on how humans choose their partners, a scientist will tell the annual conference of the European Society of Human Genetics today (Monday May 25). Professor Maria da Graça Bicalho, head of the Immunogenetics and Histocompatibility Laboratory at the University of Parana, Brazil, says that her research had shown that people with diverse major histocompatibility complexes (MHCs) were more likely to choose each other as mates than those whose MHCs were similar, and that this was likely to be an evolutionary strategy to ensure healthy reproduction.

Dr. William Phillips, an Office of Naval Research (ONR) funded Nobel Prize-winning physicist, delivered the final lecture at ONR's spring distinguished lecture series May 19. Phillips' compelling presentation, titled "Time, Einstein and the Coolest Stuff," highlighted the importance of basic research and ONR's legacy of support for innovative scientists.

The International Institute for Species Exploration at Arizona State University and an international committee of taxonomists – scientists responsible for species exploration and classification – today announce the top 10 new species described in 2008.

New research provides exciting genetic insight into a rare syndrome that first appeared in the medical literature in the mid 1800s with the case of Julia Pastrana, the world's most notorious bearded lady. The study, published by Cell Press in the May 21st issue of the American Journal of Human Genetics, reveals intriguing molecular clues about the pathogenesis of this mysterious condition that has captured the attention of the public since the Middle Ages.

For decades scientists have been intrigued by the variety of sounds emitted by sperm whales, partly due to a popular theory that suggests that the sounds might contain information about the animals' size. But historically it has been extremely difficult to demonstrate that these curious clicking noises can reveal information about the physical characteristics of the massive marine mammals. Now, researchers at Scripps Institution of Oceanography at UC San Diego are unlocking some of the mysteries of sperm whale sound production.

New Rochelle, NY, May 20, 2009—Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) The article is available free online at www.liebertpub.com/oli

Researchers in the "Molecular Infection Biology group" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Braunschweig Technical University could now demonstrate for the first time that bacteria of the Yersinia genus possess a unique protein thermometer – the protein RovA - which assists them in the infection process. RovA is a multi-functional sensor: it measures both the temperature of its host as well as the host's metabolic activity and nutrients. If these are suitable for the survival of the bacteria, the RovA protein activates genes for the infection process to begin. These results have now been published in the current online edition of the PLoS Pathogens science magazine.

Scientists have called it "junk DNA." They have long been perplexed by these extensive strands of genetic material that dominate the genome but seem to lack specific functions. Why would nature force the genome to carry so much excess baggage?

The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases Program, or TRND.

Scientists at Queen's University Belfast have discovered a new eco-friendly way of dissolving wood using ionic liquids that may help its transformation into popular products such as bio fuels, textiles, clothes and paper.

The bombardment of Earth nearly 4 billion years ago by asteroids as large as Kansas would not have had the firepower to extinguish potential early life on the planet and may even have given it a boost, says a new University of Colorado at Boulder study.

Most cancers are rare in people with Down syndrome, whose overall cancer mortality is below 10 percent of that in the general population. Since they have an extra copy of chromosome 21, it's been proposed that people with Down syndrome may be getting an extra dose of one or more cancer-protective genes. The late cancer researcher Judah Folkman, MD, founder of the Vascular Biology Program at Children's Hospital Boston, popularized the notion that they might be benefiting from a gene that blocks angiogenesis, the development of blood vessels essential for cancer's growth, since their incidence of other angiogenesis-related diseases like macular degeneration is also lower. A study from Children's confirms this idea in mice and human cells and identifies specific new therapeutic targets for treating cancer.

Using a system of underwater hydrophones that can record sounds from hundreds of miles away, a team of scientists from Oregon State University and the National Oceanic and Atmospheric Administration has documented the presence of endangered North Atlantic right whales in an area they were thought to be extinct.

Octopuses and squid are big brained species that use much of their mental powers to adjust their own appearances. This remarkable ability to camouflage on the fly has inspired the Office of Naval Research to award $7.5 million to Duke University and two collaborating institutions to learn more about how the animals do it.

By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of a human hair. These tiny structures could be forerunners of custom-made biomedical nanodevices such as "smart" delivery vehicles that would sneak drugs into patients' cells, where they would dump their cargo on a specific molecular target.

A study of venomous snails on remote Pacific islands reveals genetic underpinnings of an ecological phenomenon that has fascinated scientists since Darwin.

They are cursed the world over for contaminating food supplies and are a huge commercial pest, but the humble flour beetle is about to play a significant role in the management of endangered species.

What happens if the next big influenza mutation proves resistant to the available anti-viral drugs? This question is presenting itself right now to scientists and health officials this week at the World Health Assembly in Geneva, Switzerland, as they continue to do battle with H1N1, the so-called swine flu, and prepare for the next iteration of the ever-changing flu virus.

The carnivorous reptiles (Varanus komodoensis) are known to bite prey and release them, leaving them to bleed to death from their wounds: the victims are reported to go into shock before the dragons kill and eat them.

A novel vaccine strategy using virus-like particles (VLPs) could provide stronger and longer-lasting influenza vaccines with a significantly shorter development and production time than current ones, allowing public health authorities to react more quickly in the event of a potential pandemic.

A team of University of Oregon biologists, using fruit flies, has created a way to isolate RNA from specific cells, opening a new window on how gene expression drives normal development and disease-causing breakdowns.

The 57-year-old lawyer in New York had handily completed the New York Times' Saturday crossword puzzle – the hardest of the week – for years. But one Saturday morning, suddenly he couldn't retrieve the words to fill in the squares.

The instruction manual for maintaining an efficient brain may soon include a section on synaptotagmin-IV (Syt-IV), a protein known to influence learning and memory, thanks to a study by University of Wisconsin-Madison researchers.

For modern implants and the growth of artificial tissue and organs, it is important to generate materials with characteristics that closely emulate nature. However, the tissue in our bodies has a combination of traits that are very hard to recreate in synthetic materials: It is both soft and very tough. A team of Australian and Korean researchers led by Geoffrey M. Spinks and Seon Jeong Kim has now developed a novel, highly porous, sponge-like material whose mechanical properties closely resemble those of biological soft tissues. As reported in the journal Angewandte Chemie, it consists of a robust network of DNA strands and carbon nanotubes.

The recent H1N1 influenza epidemic has raised many questions about how animal viruses move to human populations. One potential route is through veterinarians, who, according to a new report by University of Iowa College of Public Health researchers, are at markedly increased risk of infection with zoonotic pathogens -- the viruses and bacteria that can infect both animals and humans.

Researchers at the University of Gothenburg, Sweden, have developed a new method to study single cells while exposing them to controlled environmental changes. The unique method, where a set of laser tweezers move the cell around in a microscopic channel system, allows the researchers to study how single cells react to stress induced by a constantly changing environment.

Any child confronting an outraged parent demanding to know "What were you thinking?" now has a new response: "Scientists have discovered that my brain is organized differently than yours."