Despite the popular notion that antioxidants, such as vitamins C and E, offer health-promoting benefits by protecting against damaging free radicals, a new study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure.

It may not be inhaled into the lungs, but smokeless tobacco exposes users to some of the same potent carcinogens as cigarettes. In the August issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, researchers at the University of Minnesota Cancer Center report that users of smokeless tobacco are exposed to higher amounts of tobacco-specific nitrosamines -- molecules that are known to be carcinogenic -- than smokers.

Three Magellanic penguins in the new marine park declared by Argentina on Aug. 8. Over half a million of these marine birds will call home to this new protected area. The Bronx Zoo-based Wildlife Conservation Society announced today that the government of Argentina will create a new marine park along its isolated and windswept Patagonia coast to safeguard more than half a million penguins and other rare seabirds. Located in Golfo San Jorge, the new protected area covers around 250 square miles (647 square kilometers) of coastal waters and nearby islands strung along almost 100 miles (160 kilometers) of shoreline.

A new regional study shows that land-use policies in Peru have been key to tempering rain forest degradation and destruction in that country. Scientists at the Carnegie Institution’s Department of Global Ecology led an international effort to analyze seven years of high-resolution satellite data covering most (79%) of the Peruvian Amazon for their findings. The work is published in the August 9, 2007, on-line edition of Science Express.

When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

Preparing vaccines and therapeutics that target a future mutant strain of H5N1 influenza virus sounds like science fiction, but it may be possible, according to a team of scientists at the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health (NIH), and a collaborator at Emory University School of Medicine. Success hinges on anticipating and predicting the crucial mutations that would help the virus spread easily from person to person.

Which genes are passed on from mother to child is decided very early on during the maturation of the egg cell in the ovary. In a cell division process that is unique to egg cells, half of the chromosomes are eliminated from the egg before it is fertilised. Using a powerful microscope, researchers from the European Molecular Biology Laboratory (EMBL) have now revealed how the molecular machinery functions that is responsible for chromosome reduction of egg cells in mice. In the current issue of Cell they report the assembly of this machinery, which is very different from what happens in all other cells in the body. The process is likely conserved across species and the new insights might help shed light on defects occurring in human egg cell development.

An undisturbed, virgin rainforest where the research team worked. The long-held belief that plant-eating insects in tropical forests are picky eaters that stay “close to home” – dining only on locale-specific vegetation – is being challenged by new research findings that suggest these insects feast on a broader menu of foliage and can be consistently found across hundreds of miles of tropical forestland.

In a paper published today in the journal Science, scientists from deCODE genetics (Nasdaq:DCGN) and academic colleagues from the National University Hospital in Reykjavik and Uppsala University in Sweden report the discovery of two common single letter variations (SNPs) in the sequence of the human genome that appear to account for virtually all cases of a major subtype of glaucoma. The SNPs are located in the LOXL1 gene on chromosome 15, and confer respectively 26-fold and 8-fold increases in risk of exfoliation glaucoma compared to the low-risk versions of the same markers. Approximately 25% of those in the Icelandic and Swedish study cohorts were found to have two copies of the highest risk variant, putting them at approximately 100 times the likelihood of developing exfoliation glaucoma (XFG) as are individuals with the low risk version of the same SNP. The LOXL1 protein encoded by the gene is involved in the formation of elastin fibers which, when they accumulate in the eye, cause XFG.

It is not just what’s in your genes, it’s how you turn them on that accounts for the difference between species — at least in yeast — according to a report by Yale researchers in this week’s issue of Science.