
The electron tomogram of a complete yeast cell reveals the cellular architecture. It shows plasma membrane, microtubules and light vacuoles (green), nucleus, dark vacuoles and dark vesicles (gold), mitochondria and large dark vesicles (blue) and light vesicles (pink). Credit: Johanna Höög, EMBL Heidelberg Editor: A high resolution version of the picture is available!
Like our body every cell has a skeleton that provides it with a shape, confers rigidity and protects its fragile inner workings. The cytoskeleton is built of long protein filaments that assemble into networks whose overall architecture and fine detail can only be revealed with high resolution electron microscopy images. Researchers at the European Molecular Biology Laboratory (EMBL) and the University of Colorado have now obtained the first 3D visualization of a complete eukaryotic cell at a resolution high enough to resolve the cytoskeleton's precise architectural plan in fission yeast. The image of this unicellular organism will be published in this week's issue of the journal Developmental Cell and reveals remarkable insights into the fine structure of the cytoskeleton as well as its interactions with other parts of the cell.