Taking a new approach to the painstaking assembly of nanometer-sized machines, a team of scientists at the University of Wisconsin-Madison has successfully used single bacterial cells to make tiny bio-electronic circuits.

An international team of marine ecologists is urging the United States to take immediate action to save its fragile coral reefs. Their message is contained a strongly worded essay titled, "Are U.S. Coral Reefs on the Slippery Slope to Slime?" that appears in the March 18 edition of the journal Science.

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they say could lead to new drug interventions and possibly gene therapy, today at the 229th national meeting of the American Chemical Society, the world's largest scientific society.

Development of robust and efficient methods for analyzing and interpreting high dimension gene expression profiles continues to be a focus in computational biology. The accumulated experiment evidence supports the assumption that genes express and perform their functions in modular fashions in cells. Therefore, there is an open space for development of the timely and relevant computational algorithms that use robust functional expression profiles towards precise classification of complex human diseases at the modular level.

Abstract : Recently, researchers have made some progress in using microarrays to validate predicted exons in genome sequence and find new gene structures. However, current methods rely on separately making threshold-based decisions on intensity of expression, similarity of expression profiles, and arrangements of exons in the genome.