Bioinformatics


Grains of rice reveal just a tiny proportion of the variation of traits in the over 40,000 different varieties of rice in the world.
The open-access, open-data journal GigaScience (published by BGI and Biomed Central), announces today the publication of an article on the genome sequencing of 3000 rice strains along with the release of this entire dataset in a citable format in journal's affiliated open-access database, GigaDB. The publication and release of this enormous data set (which quadruples the current amount of publicly available rice sequence data) coincides with World Hunger Day to highlight one of the primary goals of this project— to develop resources that will aid in improving global food security, especially in the poorest areas of the world. This work is the completion of stage one of the 3000 Rice Genomes Project, a collaborative effort made up of the Chinese Academy of Agricultural Sciences (CAAS), the International Rice Research Institute (IRRI), and BGI, and is funded by the Bill and Melinda Gates Foundation and the Chinese Ministry of Science and Technology.

Biotechnology


The 3-D lung tumor model helps researchers to test medications.
Lung cancer is a serious condition. Once patients are diagnosed with it, chemotherapy is often their only hope. But nobody can accurately predict whether or not this treatment will help. To start with, not all patients respond to a course of chemotherapy in exactly the same way. And then there's the fact that the systems drug companies use to test new medications leave a lot to be desired. "Animal models may be the best we have at the moment, but all the same, 75 percent of the drugs deemed beneficial when tested on animals fail when used to treat humans," explains Prof. Dr. Heike Walles, head of the Würzburg-based "Regenerative Technologies for Oncology" project group belonging to the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB.

Molecular & Cell Biology

By cataloging over 18,000 proteins, researchers from TUM have produced an almost complete inventory of the human proteome. This information is now freely available in the ProteomicsDB database, which is a joint development of TUM and software company SAP. The database includes information for example on the types, distribution, and abundance of proteins in various cells and tissues as well as in body fluids.

Health & Medicine

A multi-institutional team of researchers has pinpointed exactly what goes wrong when chronic lymphocytic leukemia (CLL) patients develop resistance to ibrutinib, a highly effective, precisely targeted anti-cancer drug. In a correspondence published online May 28 in the New England Journal of Medicine, they show how the mutation triggers resistance. Their finding could guide development of new agents to treat drug-resistant disease.


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