Bioinformatics

Decades after the genomics revolution, half of known eukaryote lineages still remain unstudied at the genomic level--with the field displaying a research bias against 'less popular', but potentially genetically rich, single-cell organisms.

Molecular & Cell Biology


This is a fatty liver with SIRT7. The microscope images show the liver tissue of control animals (left) and mice that lack the SIRT7 gene magnified by a factor of...
The long-term consumption of too much high-energy and high-fat food leads to overweight. Behind this trivial statement lies the extremely complex regulation of lipid metabolism. Together with colleagues from Japan, scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the Sirt7 gene plays a central role in energy metabolism. Despite consuming high-fat food, genetically modified mice that lack the gene maintain their normal weight.

Biotechnology


This is a full section of a tissue construct with cartilage at the top and bone substrate underneath.
Researchers at Columbia Engineering announced today that they have successfully grown fully functional human cartilage in vitro from human stem cells derived from bone marrow tissue. Their study, which demonstrates new ways to better mimic the enormous complexity of tissue development, regeneration, and disease, is published in the April 28 Early Online edition of Proceedings of the National Academy of Sciences (PNAS).

Stem Cell Research


This is the distinct neuronal-like appearance of a mouse-derived dental pulp stem cell following the induction process.
University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could one day be used in the brain as a therapy for stroke.


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