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Molecular & Cell Biology

Cancer is a difficult disease to treat because it's a personal disease. Each case is unique and based on a combination of environmental and genetic factors. Conventional chemotherapy employs treatment with one or more drugs, assuming that these medicines are able to both "diagnose" and "treat" the affected cells. Many of the side effects experienced by chemotherapy patients are due to the fact that the drugs they are taking aren't selective enough. For instance, taking a drug that targets fast-growing tumor cells frequently results in hair loss, because cells in the hair follicle are among some of the fastest growing in the body. When it comes down to it, these drugs get the diagnosis wrong.

Bioinformatics

The first entire genome of an Irish individual has been sequenced. The sequence is reported in BioMed Central's open access journal, Genome Biology and provides insight into the evolutionary history of this distinct lineage.

Environment

Using sophisticated airborne imaging and structural analysis, scientists at the Carnegie Institution's Department of Global Ecology mapped more than 40,000 termite mounds over 192 square miles in the African savanna. They found that their size and distribution is linked to vegetation and landscape patterns associated with annual rainfall. The results reveal how the savanna terrain has evolved and show how termite mounds can be used to predict ecological shifts from climate change. The research is published in the September 7, 2010, advanced online edition of Nature Communications.