Molecular & Cell Biology

Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease.

Microbiology

Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV). The new antibody effectively neutralized the virus in culture, and then prevented infection by the virus in a pre-clinical animal model of the disease.

Microbiology

The swine flu outbreak that began in Mexico and continues to spread around the globe may be particularly dangerous for young, otherwise healthy adults because it contains genetic components of the H5N1 avian influenza virus, which can induce a "cytokine storm," in which a patient's hyper-activated immune system causes potentially fatal damage to the lungs. Research studies and review articles exploring the regulation of cytokine responses in the lung and how infection-related dysregulation can cause a cytokine storm have been published in Viral Immunology, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com/vim).

Molecular & Cell Biology

One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair.

Environment

'Drought-proofing' Australia's urban regions by installing large domestic water tanks may enable the dengue mosquito Aedes aegypti to regain its foothold across the country and expand its range of possible infections, according to a new study published May 5 in the open-access journal PLoS Neglected Tropical Diseases.

Microbiology

As the swine flu continues its global spread, researchers from the Children's Hospital of Philadelphia, Pennsylvania, have discovered important clues about why influenza is more severe in some people than it is in others. In their research study published online in the Journal of Leukocyte Biology (http://www.jleukbio.org), the scientists show that the influenza virus can actually paralyze the immune systems of otherwise healthy individuals, leading to severe secondary bacterial infections, such as pneumonia. Furthermore, this immunological paralysis can be long-lived, which is important to know when developing treatment strategies to combat the virus.




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