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Microarray

The most comprehensive to-date genomic analysis of a cancer – the deadly brain tumor glioblastoma multiforme – shows previously unrecognized changes in genes and provides an overall view of the missteps in the pathways that govern the growth and behavior of cells, said members of The Cancer Genome Atlas Research Network in a report that appears online today in the journal Nature.

Biology

Bumblebees learn to avoid camouflaged predators by sacrificing foraging speed for predator detection, according to scientists from Queen Mary, University of London.

Biology

The largest study ever conducted of DNA evidence extracted from long-dead woolly mammoths points to a rockier past for the iconic Ice Age giants than many had suspected.

AIDS & HIV

Researchers have discovered a new 'trick' that allows HIV to overtake resting T cells that are normally highly resistant to HIV infection, according to a report in the September 5th issue of the journal Cell, a Cell Press publication. The binding of the virus to the surface of those cells sends a signal that breaks down the cells' internal skeleton, a structure that otherwise may present a significant barrier to infection.

Molecular & Cell Biology

A new mouse model has provided some surprising insight into XLF, a molecule that helps to repair lethal DNA damage. The research, published by Cell Press in the September 5th issue of the journal Molecular Cell, suggests that although XLF shares many properties with well known DNA repair factors, certain cells of the immune system possess an unexpected compensatory mechanism that that can take over for nonfunctional XLF.

Stem Cell Research

Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 – the aberrant inheritance of which results in the condition. Their study is published online today (Thursday 4 September) in the American Journal of Human Genetics.

Molecular & Cell Biology

Why is it that the origins of many serious diseases remain a mystery? In considering that question, a scientist at the University of California, San Diego School of Medicine has come up with a unified molecular view of the indivisible unit of life, the cell, which may provide an answer.

Biology


The big-eared horseshoe bat, Rhinolophus macrotis.
Echolocation may have evolved more than once in bats, according to new research from the University of Bristol published this week in Proceedings of the National Academy of Sciences (PNAS).

Health & Medicine

Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or – on the contrary – absence of characteristic proteins in the renal cells. An international research team under the leadership of scientists from DKFZ and Heidelberg University Hospitals has now developed an animal model to better investigate these conditions.