Angiogenesis, the growth of new blood vessels, is a central process in diverse physiological and pathological situations such as healing of wounds and traumas, cardiovascular disorders, inflammatory conditions such as rheumatoid arthritis, and in cancer growth. The current belief about the source of blood vessel wall endothelial cells (ECs) responsible for vascular growth in adults is that a significant and crucial part of neovascular ECs originate from circulating stem and progenitor cells that are first mobilized from the bone marrow (BM), and subsequently differentiate to mature bona fide ECs and incorporate in the vasculature. This concept has become textbook material, and a common theme in modem vascular and cancer biology.

Using a common virus as a tool for investigating abnormal cell proliferation, a team led by scientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in clarifying an intricate series of biochemical steps that shed light on a way that cancer can begin.

While waiting for colleagues at a small natural history museum in the state of Chiapas, Mexico last year, Cornell paleontologist Greg Dietl chanced upon a discovery that has helped rewrite the evolutionary history of crabs and the shelled mollusks upon which they preyed.

For the first time, researchers have peered deeply at the atomic level into the protein that causes hereditary cerebral amyloid angiopathy (CAA) -- a disease thought to cause stroke and dementia.

Red colobus monkeys living in a park in western Uganda harbored antibodies to an unknown orthopoxvirus, a pathogen that is related to the viruses that cause smallpox, monkeypox and cowpox. Researchers report this month that red colobus monkeys in a park in western Uganda have been exposed to an unknown orthopoxvirus, a pathogen related to the viruses that cause smallpox, monkeypox and cowpox. Most of the monkeys screened harbor antibodies to a virus that is similar – but not identical – to known orthopoxviruses.

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice. This new finding may add to the growing arsenal of so called oncolytic viruses under development as novel cancer treatments, especially for difficult, inoperable tumors, according to a research led by Cincinnati Children’s Hospital Medical Center and published April 24 in Molecular Therapy.

New research from the Ontario Prehospital Advanced Life Support (OPALS) project shows there is no benefit — and perhaps harm — to providing advanced life support to patients with trauma injuries prior to transport to hospital.

Nasal surgery to remove obstructions from the airway is associated with improvements in quality of life for patients with obstructive sleep apnea and symptoms of nasal blockages, according to a report in the April issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals.

The human brain responds to being treated fairly the same way it responds to winning money and eating chocolate, UCLA scientists report. Being treated fairly turns on the brain's reward circuitry.

Scientists studied lizard walking and running mechanics on a race track with a built-in force plate. The technique lizards use to grab their grub influences how they move, according to researchers at Ohio University.