The 2003 epidemic of Highly Pathogenic Avian Influenza (HPAI) in the Netherlands is the only recent epidemic of HPAI in the developed world. Gert-Jan Boender and colleagues have examined the data from this outbreak and produced a model which can predict the probability of infection from one farm to another; the 'transmission kernel'. They also identify high-risk areas in the Netherlands and analyze various control strategies, concluding that in these regions an epidemic can only be brought to an end by massive culling of susceptible farms.

Mice whose brain cells respond to a flash of light are providing insight into the complexities of the sense of smell and may ultimately yield a better understanding of how the human brain works.

Scientists using the nation's newest and most capable aircraft for environmental research are launching a far-reaching field project this month to study plumes of airborne dust and pollutants that originate in Asia and journey to North America. The plumes are among the largest such events on Earth, so great in scope that scientists believe they might affect clouds and weather across thousands of miles while playing a role in global climate.

Doctors need to take concerted action to ensure that people who are at risk of heart disease receive the influenza vaccine every autumn, according to the authors of a new report published today (Wednesday 18 April) in the European Heart Journal. Their research shows that influenza epidemics are associated with a rise in deaths from heart disease and that flu can actually trigger the heart attacks that result in death.

Despite the fact that they both infect the liver, the hepatitis A and hepatitis C viruses actually have very little in common. The two are far apart genetically, are transmitted differently, and produce very different diseases. Hepatitis A spreads through the consumption of fecal particles from an infected person (in pollution-contaminated food or water, for example), but hepatitis C is generally transmitted only by direct contact with infected blood. Hepatitis A produces fever, nausea and abdominal pain that can last for weeks, but rarely lead to death; hepatitis C, by contrast, often spends decades quietly damaging the liver, until a victim’s only hope for survival is an organ transplant.

A recently discovered signaling system in the brain has just been shown to be turned on by methamphetamine, an Oregon Health & Science University study found.

Daniel O’Connor, M.D., Professor of Medicine and Pharmacology at the University of California, San Diego (UCSD) School of Medicine has studied about 265 twin pairs over the past few years, which has led him to some surprising discoveries.

In the children’s game "red light green light," winners are able to stop, and take off running again, more quickly than their comrades. New research reveals that a similar race goes on in our brains, with impulse control being the big winner.

Using a novel video-imaging system, researchers at the University of Pennsylvania School of Medicine have been able to observe proteins important in Alzheimer’s and Parkinson’s disease moving along axons, extensions of nerve cells that carry proteins away from the cell body. Understanding this process of axonal transport is important for studying many neurodegenerative diseases. The study appeared in the Journal of Neuroscience.

Tissue studies indicate that nanoparticles, engineered materials about a billionth of a meter in size, could damage DNA and lead to cancer, according to research presented at the 2007 Annual Meeting of the American Association for Cancer Research.

Cells constantly swap cargo bound in vesicles, miniscule membrane-enclosed packages of proteins and other chemicals. Before the swap can take place, the vesicle membrane must fuse with another membrane, creating channels packages can pass through.

Whiskers provide a mouse with essential information to negotiate a burrow or detect movement that could signal a predator's presence. These stiff hairs relay sensory input to the brain, which shapes neuronal activity. In a first, studies of this system by Carnegie Mellon scientists show just how well a mouse brain can compensate when limited to sensing the world through one whisker. Published April 4 in the Journal of Neuroscience, the results should help shape future studies of sensory deprivation that results from stroke or traumatic brain injury, say the authors.

Genetic and epigenetic variations ensure that no two people are exactly alike, and the same holds true for any two cancers. Now, researchers have the tools and the knowledge to help predict how individuals will respond to cancer therapies, enabling them to create more effective therapies for individual cancers – personalized medicine. At the 2007 Annual Meeting of the American Association for Cancer Research, researchers present new biomarkers – and techniques for determining biomarkers – that could determine how an individual might respond to drug or radiation therapy.