Biotechnology


With the new SIF-seq technique, mouse embryonic stem cells can be used to identify human embryonic stem cell enhancers even when the human enhancers are not present in the mouse.
An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers - sequences of DNA that act to amplify the expression of a specific gene – in the genomes of humans and other mammals. Called SIF-seq, for site-specific integration fluorescence-activated cell sorting followed by sequencing, this new technique complements existing genomic tools, such as ChIP-seq (chromatin immunoprecipitation followed by sequencing), and offers some additional benefits.

Molecular & Cell Biology

Case Western Reserve University researchers have discovered a novel population of neutrophils, which are the body's infection control workhorses. These cells have an enhanced microbial killing ability and are thereby better able to control infection.

Molecular & Cell Biology

Research from the Oklahoma Medical Research Foundation reveals a new complexity to nerve cells in the brain that could affect future therapies aimed at altering mood and memory in humans.

Biology

How does the Arctic tern (a sea bird) fly more than 80,000 miles in its roundtrip North Pole-to-South Pole migration? How does the Emperor penguin incubate eggs for months during the Antarctic winter without eating? How does the Rufous hummingbird, which weighs less than a nickel, migrate from British Columbia to Mexico? These physiological gymnastics would usually be influenced by leptin, the hormone that regulates body fat storage, metabolism and appetite. However, leptin has gone missing in birds - until now.


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