Look up "transcription"—the copying of a gene's DNA into RNA intermediaries—in any old molecular biology text book, and it all seems very simple: RNA polymerase II, the enzyme that catalyzes the reaction, assembles at the start site and starts motoring down the strand, cranking out the RNA ribbon used to construct proteins. But researchers now know that RNA polymerase II often stalls on DNA strands where it was once assumed to just barrel down.

A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been developed by Cardiff University scientists.

n international team of scientists has discovered that the female ancestor of all living polar bears was a brown bear that lived in the vicinity of present-day Britain and Ireland just prior to the peak of the last ice age An international team of scientists has discovered that the female ancestor of all living polar bears was a brown bear that lived in the vicinity of present-day Britain and Ireland just prior to the peak of the last ice age -- 20,000 to 50,000 years ago. Beth Shapiro, the Shaffer Associate Professor of Biology at Penn State University and one of the team's leaders, explained that climate changes affecting the North Atlantic ice sheet probably gave rise to periodic overlaps in bear habitats. These overlaps then led to hybridization, or interbreeding -- an event that caused maternal DNA from brown bears to be introduced into polar bears. The research, which is led by Shapiro and Daniel Bradley of Trinity College Dublin, is expected to help guide future conservation efforts for polar bears, which are listed as threatened under the Endangered Species Act. The results of the study will be published on 7 July 2011 in the journal Current Biology.