When faced with adversity, some people succumb to debilitating psychological diseases including posttraumatic stress disorder and depression, while others are able to remain remarkably optimistic. Now, a new mouse study in the October 19 issue of the journal Cell, a publication of Cell Press, reveals that the difference may depend in part on the chemistry of the brains’ reward circuits. The findings could point to new psychiatric drugs, and perhaps even new ways to encourage resilience for people in high-stress circumstances, including soldiers in combat, disaster relief workers, and disaster victims, according to the researchers.


