Were Neanderthals direct ancestors of contemporary humans or an evolutionary side branch that eventually died out? This is one of the enduring questions in human evolution as scientists explore the relationship of fossil groups, such as Neanderthals, with people alive today. Two recent papers describing the sequencing of Neanderthal nuclear DNA from fossil bone held promise for finally answering this question [1, 2]. However, the two studies came to very different conclusions regarding the ancestral role of Neanderthals. Jeffrey D. Wall and Sung K. Kim from University of California San Francisco now reveal in PLoS Genetics what they found when they reanalyzed the data from the two original studies.