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[Perspective] Bringing proteins into the fold

ScienceNOW - Fetched: March 23rd, 2017, 3:00pm UTC

Molecular engineers have become increasingly adept at repurposing life's building blocks to make custom self-assembled shapes. Because a single drop of solution contains billions of such shapes, DNA origami smiley faces (1), RNA stars (2), and designer protein polyhedra (3) may vastly outnumber most other human-made objects on Earth. These shapes lack immediate practical utility, but they transmit a powerful message: Researchers are beginning to understand how molecules self-assemble. On page 1283 of this issue, Praetorius and Dietz make another leap forward by demonstrating a novel class of nanostructures, namely DNA-protein hybrid shapes (4). This is an important advance because it provides a method to create human-designed shapes out of ingredients that are generally compatible with living systems. Author: Shawn M. Douglas

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