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June 02, 2016

[In Depth] CRISPR views of embryos and cells

ScienceNOW - Fetched: June 2nd, 2016, 4:00pm UTC
Two teams have developed innovative new applications of the popular genome-editing method CRISPR. One of the groups has used it to mark and trace cells in a developing animal. In the method's first test, described online today in Science, the researchers reveal that many tissues and organs in adult zebrafish form from just a few embryonic cells. Other researchers are already looking to adapt the method to mice, or to exploit it to trace the evolution of tumors. The second group found a way to use CRISPR-guided mutations to record a cell's history—for example, the environmental signals that influence it. Author: Kai Kupferschmidt

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