Breast cancer cells frequently move from their primary site and invade bone, decreasing a patient's chance of survival. This process of metastasis is complex, and factors both within the breast cancer cells and within the new bone environment play a role. In next week's Journal of Biological Chemistry "Paper of the Week," Roger Gomis and colleagues at the Institute for Research in Biomedicine in Spain investigated how breast cancer cells migrate to bone.

New evidence challenges the idea that the Amazon basin was densely inhabited before European arrival. Population estimates for the Amazon basin just before Europeans arrived range from 2 to 10 million people. The newly reported reconstruction of Amazonian prehistory by Smithsonian scientist Dolores R. Piperno and colleagues suggests that large areas of western Amazonia were sparsely inhabited. This clashes with the belief that most of Amazonia, including forests far removed from major rivers, was heavily occupied and modified. The team's research is published in the June 15 issue of Science.

It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive.