Brain and spinal cord comprise more than just nerve cells. The extracellular matrix, a complex scaffold of proteins with sugar residues, surrounds the cells and influences their well-being. Prof. Wiese's team is interested in the interaction of the matrix with a specific kind of nerve cells, which transmit signals from the brain to muscles (motoneurons). Because injured motoneurons lead to paralysis, clinicians have great interest in being able to influence the growth of these cells. "If we had a medication that could change the extracellular matrix so that it favours the growth and survival of nerve cells, that would be a large step in the treatment of nerve injuries after accidents or also for the treatment of diseases such as Multiple Sclerosis", says Prof. Wiese.