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November 15, 2015

Experimental Drug Targeting Alzheimer's Disease Shows Anti-Aging Effects

Slashdot: Science - Fetched: November 15th, 2015, 10:00pm UTC
schwit1 writes with news that researchers at the Salk Institute have found that an experimental drug candidate aimed at combating Alzheimer's disease has a host of unexpected anti-aging effects in animals. Says the article: The Salk team expanded upon their previous development of a drug candidate, called J147, which takes a different tack by targeting Alzheimer's major risk factorndash;old age. In the new work, the team showed that the drug candidate worked well in a mouse model of aging not typically used in Alzheimer's research. When these mice were treated with J147, they had better memory and cognition, healthier blood vessels in the brain and other improved physiological features. "Initially, the impetus was to test this drug in a novel animal model that was more similar to 99 percent of Alzheimer's cases," says Antonio Currais, the lead author and a member of Professor David Schubert's Cellular Neurobiology Laboratory at Salk. "We did not predict we'd see this sort of anti-aging effect, but J147 made old mice look like they were young, based upon a number of physiological parameters."pdiv class="share_submission" style="position:relative;" a class="slashpop" href="http://twitter.com/home?status=+Experimental+Drug+Targeting+Alzheimer's+Disease+Shows+Anti-Aging+Effects%3A+http%3A%2F%2Fbit.ly%2F1LgW41C"img src="http://slashcdn.com/sd/twitter_icon_large.png"/a a class="slashpop" href="http://www.facebook.com/sharer.php?u=http%3A%2F%2Fscience.slashdot.org%2Fstory%2F15%2F11%2F15%2F2151232%2Fexperimental-drug-targeting-alzheimers-disease-shows-anti-aging-effects%3Futm_source%3Dslashdot%26utm_medium%3Dfacebook"img src="http://slashcdn.com/sd/facebook_icon_large.png"/a a class="nobg" href="http://plus.google.com/share?url=http://science.slashdot.org/story/15/11/15/2151232/experimental-drug-targeting-alzheimers-disease-shows-anti-aging-effects?utm_source=slashdotamp;utm_medium=googleplus" onclick="javascript:window.open(this.href,'', 'menubar=no,toolbar=no,resizable=yes,scrollbars=yes,height=600,width=600');return false;"img src="http://www.gstatic.com/images/icons/gplus-16.png" alt="Share on Google+"//a /div/ppa href="http://science.slashdot.org/story/15/11/15/2151232/experimental-drug-targeting-alzheimers-disease-shows-anti-aging-effects?utm_source=rss1.0moreanonamp;utm_medium=feed"Read more of this story/a at Slashdot./pimg src="http://feeds.feedburner.com/~r/Slashdot/slashdotScience/~4/29SiuxdTxtQ" height="1" width="1" alt=""/

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