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July 22, 2014

Researchers Successfully Cut HIV DNA Out of Human Cells

Slashdot: Science - Fetched: July 22nd, 2014, 8:00pm EDT
mrspoonsi sends word that researchers from Temple University have managed to eliminate the HIV-1 virus from human cells for the first time. "When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and excise the HIV-1 DNA (abstract). From there, the cell's gene repair machinery takes over, soldering the loose ends of the genome back together ndash; resulting in virus-free cells." While antiretroviral therapy can treat people who are infected with HIV, the immune system is incapable of actually removing the virus, so this is an important step in fighting it. The researchers still have to overcome the problem of delivering the the genetic "toolkit" to each affected cell in a patient's body, and also HIV's high mutation rate.pdiv class="share_submission" style="position:relative;" a class="slashpop" href="http://twitter.com/home?status=Researchers+Successfully+Cut+HIV+DNA+Out+of+Human+Cells%3A+http%3A%2F%2Fbit.ly%2F1ucMsmv"img src="http://a.fsdn.com/sd/twitter_icon_large.png"/a a class="slashpop" href="http://www.facebook.com/sharer.php?u=http%3A%2F%2Fscience.slashdot.org%2Fstory%2F14%2F07%2F22%2F2053257%2Fresearchers-successfully-cut-hiv-dna-out-of-human-cells%3Futm_source%3Dslashdot%26utm_medium%3Dfacebook"img src="http://a.fsdn.com/sd/facebook_icon_large.png"/a a class="nobg" href="http://plus.google.com/share?url=http://science.slashdot.org/story/14/07/22/2053257/researchers-successfully-cut-hiv-dna-out-of-human-cells?utm_source=slashdotamp;utm_medium=googleplus" onclick="javascript:window.open(this.href,'', 'menubar=no,toolbar=no,resizable=yes,scrollbars=yes,height=600,width=600');return false;"img src="http://www.gstatic.com/images/icons/gplus-16.png" alt="Share on Google+"//a /div/ppa href="http://science.slashdot.org/story/14/07/22/2053257/researchers-successfully-cut-hiv-dna-out-of-human-cells?utm_source=rss1.0moreanonamp;utm_medium=feed"Read more of this story/a at Slashdot./pimg width='1' height='1' src='http://slashdot.feedsportal.com/c/35028/f/647403/s/3cc362b8/sc/14/mf.gif' border='0'/br clear='all'/br/br/a href="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/1/rc.htm" rel="nofollow"img src="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/1/rc.img" border="0"//abr/a href="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/2/rc.htm" rel="nofollow"img src="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/2/rc.img" border="0"//abr/a href="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/3/rc.htm" rel="nofollow"img src="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/rc/3/rc.img" border="0"//abr/br/a href="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/a2.htm"img src="http://da.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/a2.img" border="0"//aimg width="1" height="1" src="http://pi.feedsportal.com/r/199120895765/u/49/f/647403/c/35028/s/3cc362b8/sc/14/a2t.img" border="0"/img src="http://feeds.feedburner.com/~r/Slashdot/slashdotScience/~4/HGrTdnQAW5o" height="1" width="1"/

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