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[Research Article] IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

ScienceNOW - Fetched: May 12th, 2016, 5:00pm UTC

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells undergo prolonged interactions with SED dendritic cells (DCs). PP IgA class switching requires innate lymphoid cells, which promote lymphotoxin-β receptor (LTβR)–dependent maintenance of DCs. PP DCs augment IgA production by integrin αvβ8-mediated activation of transforming growth factor–β (TGFβ). In mice where B cells cannot access the SED, IgA responses against oral antigen and gut commensals are impaired. These studies establish the PP SED as a niche supporting DC–B cell interactions needed for TGFβ activation and induction of mucosal IgA responses. Authors: Andrea Reboldi, Tal I. Arnon, Lauren B. Rodda, Amha Atakilit, Dean Sheppard, Jason G. Cyster

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