Bioinformatics

A novel software tool, developed at The Children's Hospital of Philadelphia, streamlines the detection of disease-causing genetic changes through more sensitive detection methods and by automatically correcting for variations that reduce the accuracy of results in conventional software. The software, called ParseCNV, is freely available to the scientific-academic community, and significantly advances the identification of gene variants associated with genetic diseases.

Molecular & Cell Biology


Dendritic cells, shown here in an electron microscopic picture, need antibodies produced by B cells for their maturation.
Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface. This in turn signals other immune cells capable of recognizing these pieces to help kick-start their own default program for fighting off the invaders. In order to do their job, the DCs are dependent upon the support from a class of immune system molecules, which have never before been associated with dendritic cells: antibodies, best known for their role in vaccinations and diagnostics. Now, scientists at the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH) were able to show that antibodies are essential for dendritic cell maturation. The researchers' findings have been published in the renowned scientific journal, Proceedings of the National Academy of Sciences (PNAS).




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