Perilous and polluting industrial processes can be made safer with enzymes. But only a short range of enzymes have been available for the chemical industry.

Groups of neurons that precisely keep time have been discovered in the primate brain by a team of researchers that includes Dezhe Jin, assistant professor of physics at Penn State University and two neuroscientists from the RIKEN Brain Science Institute in Japan and the Massachusetts Institute of Technology (MIT). "This research is the first time that precise time-keeping activities have been identified in recordings of neuron activity," Jin said. The time-keeping neurons are in two interconnected brain regions, the prefrontal cortex and the striatum, both of which are known to play critical roles in learning, movement, and thought control.

A study from the University of North Carolina at Chapel Hill has identified a key player in a molecular process essential for DNA replication within cells.

Two in five at-risk American adults who would benefit from vaccination against seasonal flu are missing out on the protective shots because they believe they do not need them and are not inclined to be vaccinated. And among those who say they do intend to take up the vaccine, nearly half get around to it, according to Dr. Katharine Harris from the RAND Corporation* in Arlington, USA, and her team. Their work (1) shows that asking simple questions about the intention to be protected against flu may be an effective way of identifying those patients who are likely to benefit from further information and discussion about the benefits of the vaccine, in order to increase its uptake. Their findings are published online this week in the Journal of General Internal Medicine, published by Springer.

Drugs based on engineered proteins represent a new frontier for pharmaceutical makers. Even after they discover a protein that may form the basis of the next wonder drug, however, they have to confront a long-standing problem: how to produce large quantities of the protein in a highly pure state. Now, a multi-institutional research team including a biochemist at the National Institute of Standards and Technology (NIST) may have found* a new solution in an enzymatic "food processor" they can activate at will.

Highly active antiretroviral therapy has increased the longevity and quality of life for people living with human immunodeficiency virus. But it requires strict adherence in taking the medicine, something that is extremely difficult for many individuals to do.