Gene Therapy

Scientists from the Universities of Michigan and Minnesota show in a research report published online in the FASEB Journal (http://www.fasebj.org) that gene therapy may be used to improve an ailing heart's ability to contract properly. In addition to showing gene therapy's potential for reversing the course of heart failure, it also offers a tantalizing glimpse of a day when "closed heart surgery" via gene therapy is as commonly prescribed as today's cocktail of drugs.

Molecular & Cell Biology

Multiple myeloma cancer cells thwart many of the drugs used against them by causing nearby cells to turn traitor – to switch from defending the body against disease to shielding the myeloma cells from harm – Dana-Farber Cancer Institute scientists report in the October issue of Cancer Cell.

Biology

Seven new glow-in-the-dark mushroom species have been discovered, increasing the number of known luminescent fungi species from 64 to 71. Reported today in the journal Mycologia, the new finds include two new species named after movements in Mozart's Requiem. The discoveries also shed light on the evolution of luminescence, adding to the number of known lineages in the fungi 'family tree' where luminescence has been reported.

Molecular & Cell Biology

A new drug designed to "seek and destroy" common cancers such as breast, prostate, endometrial, pancreatic, ovarian, skin and testicular cancers is being tested at TGen Clinical Research Services (TCRS) at Scottsdale Healthcare.

Microbiology

Knowing what causes a disease may not make it easier to control and contain infection, but understanding how humans become infected and where the pathogens live may improve control. A National Science Foundation grant for $1.5 million over five years will allow an international team of researchers to investigate how changes in the environment affect a deforming tropical disease called Buruli ulcer.

Biology

Now, just a few weeks after tiny, early Raptorex kriegsteini was unveiled, a new wrench has been thrown into the family tree of the tyrannosaurs. The new Alioramus altai—a horned, long-snouted, gracile cousin of Tyrannosaurus rex—shared the same environment with larger, predatory relatives. A paper published this week in the Proceedings of the National Academy of Sciences describes this exceptionally well-preserved fossil, shedding light on a previously poorly understood genus of tyrannosaurs and describing a new suite of adaptations for meat eating.

Health & Medicine

More than one million infants die each year because they are born too early, according to the just released White Paper, The Global and Regional Toll of Preterm Birth.

Health & Medicine

Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration – a second copy of an entire gene – is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system.




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