New Rochelle, NY, May 20, 2009—Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) The article is available free online at www.liebertpub.com/oli

Researchers in the "Molecular Infection Biology group" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Braunschweig Technical University could now demonstrate for the first time that bacteria of the Yersinia genus possess a unique protein thermometer – the protein RovA - which assists them in the infection process. RovA is a multi-functional sensor: it measures both the temperature of its host as well as the host's metabolic activity and nutrients. If these are suitable for the survival of the bacteria, the RovA protein activates genes for the infection process to begin. These results have now been published in the current online edition of the PLoS Pathogens science magazine.

Scientists have called it "junk DNA." They have long been perplexed by these extensive strands of genetic material that dominate the genome but seem to lack specific functions. Why would nature force the genome to carry so much excess baggage?

The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases Program, or TRND.

Scientists at Queen's University Belfast have discovered a new eco-friendly way of dissolving wood using ionic liquids that may help its transformation into popular products such as bio fuels, textiles, clothes and paper.

The bombardment of Earth nearly 4 billion years ago by asteroids as large as Kansas would not have had the firepower to extinguish potential early life on the planet and may even have given it a boost, says a new University of Colorado at Boulder study.

Most cancers are rare in people with Down syndrome, whose overall cancer mortality is below 10 percent of that in the general population. Since they have an extra copy of chromosome 21, it's been proposed that people with Down syndrome may be getting an extra dose of one or more cancer-protective genes. The late cancer researcher Judah Folkman, MD, founder of the Vascular Biology Program at Children's Hospital Boston, popularized the notion that they might be benefiting from a gene that blocks angiogenesis, the development of blood vessels essential for cancer's growth, since their incidence of other angiogenesis-related diseases like macular degeneration is also lower. A study from Children's confirms this idea in mice and human cells and identifies specific new therapeutic targets for treating cancer.

Using a system of underwater hydrophones that can record sounds from hundreds of miles away, a team of scientists from Oregon State University and the National Oceanic and Atmospheric Administration has documented the presence of endangered North Atlantic right whales in an area they were thought to be extinct.

Octopuses and squid are big brained species that use much of their mental powers to adjust their own appearances. This remarkable ability to camouflage on the fly has inspired the Office of Naval Research to award $7.5 million to Duke University and two collaborating institutions to learn more about how the animals do it.

By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of a human hair. These tiny structures could be forerunners of custom-made biomedical nanodevices such as "smart" delivery vehicles that would sneak drugs into patients' cells, where they would dump their cargo on a specific molecular target.

A study of venomous snails on remote Pacific islands reveals genetic underpinnings of an ecological phenomenon that has fascinated scientists since Darwin.