Zebrafish offer clues to treatments for motor neurone disease

Tiny zebrafish could hold the key to stem cell treatments for motor neurone disease.

Scientists at the University of Edinburgh have found that these fish are able to produce motor neurones – cells that control all muscle activity such as speaking, walking and breathing in humans – when they repair damage to their spinal cords.

Researchers are now screening small molecules with a view to finding drugs that could kick-start the process of motor neurone regeneration in zebrafish, with a view to translating their findings into treatments for humans.

The discovery could help patients with motor neurone disease, in which the motor neurone cells die and are not replaced. This disease can cause paralysis and severe breathing difficulties and is an ultimately fatal condition for which no cure exists.

Dr Catherina Becker, from the University of Edinburgh's Centre for Neuroregeneration and Euan MacDonald Centre for Motor Neurone Disease Research, said: "Understanding how zebrafish can regenerate large numbers of motor neurones after damage to the spinal cord and how these motor neurones are produced by natural stem cells could help in finding treatments for Motor Neurone Disease.

"This could take the form of improving methods of generating motor neurones in the laboratory that could be transplanted or finding drugs which could help patients renew their motor neurone supply."

The tropical zebrafish, which are transparent and around 3 cm long, produce the motor neurones from progenitor cells found in the spinal cord that are able to turn into certain types of cells.

As well as looking at stimulating the production of motor neurones, scientists are working on ways to ensure that these cells are able to function by sending messages from the brain to the spine and then on to muscles. The research could also have implications for treating spinal cord injuries following accidents.

The research team is the first to benefit from the Edinburgh BioQuarter commercialisation initiative, funded by the University of Edinburgh and Scottish Enterprise, to assist translating research into therapies. Researchers have also received a joint grant from the Robert Packard Center in Baltimore and Euan MacDonald Centre in Edinburgh, which specialise in research into amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease.

Source : University of Edinburgh