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Category: Biotechnology

The use of next-generation gene sequencing in newborns in neonatal intensive care units (NICUs) may improve the diagnosis of rare diseases and deliver results more quickly to anxious families, according to new research in CMAJ (Canadian Medical Association Journal).

Full articleMay 30, 2016 05:23 PM302 views
Category: Health & Medicine

Early exposure to nicotine can trigger widespread genetic changes that affect formation of connections between brain cells long after birth, a new Yale-led study has found. The finding helps explains why maternal smoking has been linked to behavioral changes such as attention deficit and hyperactivity disorder, addiction and conduct disorder.

Full articleMay 30, 2016 05:23 PM230 views
Category: Molecular & Cell Biology

Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer.

Full articleMay 30, 2016 05:23 PM239 views
Category: Molecular & Cell Biology

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus--the brain's memory center--temporal ordering of the neural code is important for building a mental map of where you've been, where you are, and where you are going. Published on May 30 in Nature Neuroscience, research from the RIKEN Brain Science Institute in Japan has pinpointed how the neurons that represent space in mice stay in time.

Full articleMay 30, 2016 05:23 PM176 views
Category: Molecular & Cell Biology


Tailor-made ratiometric sensors make baker's yeast cells light up green, as Georgia Tech scientists use it to track the movements of the essential toxin heme.
A pinch of poison is good for a body, at least if it's heme.

Full articleMay 30, 2016 05:23 PM216 views
Category: Molecular & Cell Biology


Stylized graphic of SEC-SAXS data (with cyan cross-section showing the elution profile and magenta cross-section showing scattering profile) and the structure of the activated phenylalanine hydroxylase
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health. The enzyme, phenylalanine hydroxylase, turns the essential amino acid phenylalanine -- found in eggs, beef and many other foods and as an additive in diet soda -- into tyrosine, a precursor for multiple important neurotransmitters.

Full articleMay 25, 2016 05:44 PM1282 views
Category: Molecular & Cell Biology

A new study from MIT neuroscientists reveals that a gene mutation associated with autism plays a critical role in the formation and maturation of synapses -- the connections that allow neurons to communicate with each other.

Full articleMay 25, 2016 05:44 PM1305 views
Category: Bioinformatics


This image shows a range of vertebrate the G10K members are working on: Bird - Ruby-throated Hummingbird; Reptile - Green Anole; Fish - Spotted Gar; Mammal - Koala
The Genome Analysis Centre (TGAC) are to hold the biannual Genome 10K Conference on 29 August - 1 September 2017.

Full articleMay 25, 2016 05:44 PM1188 views
Category: Health & Medicine

The National Myelodysplastic Syndromes Natural History Study (The National MDS Study) is underway, the ECOG-ACRIN Cancer Research Group and its collaborators announced today. This new study, funded by the National Institutes of Health's National Heart, Lung, and Blood Institute (NHLBI), and performed in collaboration with the National Cancer Institute (NCI), will collect detailed information and biological samples from 2000 adults with myelodysplastic syndromes (MDS) and 500 more patients receiving care for a persistent low red blood cell count (anemia) that cannot be explained. Its purpose is to build a national resource to be used by scientists in future research.

Full articleMay 25, 2016 05:44 PM1215 views
Category: Molecular & Cell Biology

Unlike aspirin, bone marrow doesn't come with a neatly printed label with dosage instructions. However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

Full articleMay 25, 2016 05:44 PM1049 views
Category: AIDS & HIV

Viruses attack cells and commandeer their machinery in a complex and carefully orchestrated invasion. Scientists have longed probed this process for insights into biology and disease, but essential details still remain out of reach.

Full articleMay 24, 2016 06:13 PM1374 views
Category: Molecular & Cell Biology


These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end...
A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

Full articleMay 24, 2016 06:13 PM1263 views
Category: Bioinformatics

Whole-exome sequencing of both colorectal adenomas (precancers often called polyps) and intestinal mucosa at risk for developing into adenomas from patients with familial adenomatous polyposis (FAP) has generated a comprehensive picture of the genomic alterations that characterize the evolution of normal mucosa to precancer.

Full articleMay 24, 2016 06:13 PM1072 views
Category: Health & Medicine

A change in diet can improve the lives of those diagnosed with a common, but hard-to-treat gut disorder.

Full articleMay 24, 2016 06:13 PM901 views

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