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Category: Bioinformatics


This is a comparison of ancient rice remains and modern rice.
Rice, or Oryza sativa as its scientifically known, feeds more than a third of the globe. Yet the majority of rice crops that supply 90 percent of the world come from just two domesticated varieties, japonica and indica.

Full articleJuly 27, 2016 05:24 PM1170 views
Category: Microbiology


SPP inhibition reduces production of infectious HCV particles and pathogenesis,
Researchers at Osaka University, Japan uncovered the mechanisms that suppress the propagation of the hepatitis C virus (HCV) with the potential of improving pathological liver conditions. Using model mice, they confirmed that when a certain enzyme is inhibited, HCV particle production is reduced leading to an improvement of pathological liver conditions. They thereby identified a new drug target for the development of new HCV drugs.

Full articleJuly 27, 2016 05:24 PM713 views
Category: Gene Therapy

Eye diseases such as diabetic retinopathy and age-related macular degeneration are among the leading causes of irreversible vision loss and blindness worldwide. Currently, gene therapy can be administered to treat these conditions -- but this requires an injection. Now researchers report in the journal ACS Applied Materials & Interfaces a new way to deliver the treatment topically, without a needle.

Full articleJuly 27, 2016 05:24 PM807 views
Category: Gene Therapy

A discovery by Washington State University scientist Dan Rodgers and collaborator Paul Gregorevic could save millions of people suffering from muscle wasting disease.

Full articleJuly 27, 2016 05:24 PM585 views
Category: Health & Medicine


Berkeley Lab researchers (from left) Lara Gundel, Marion Russell, Hugo Destaillats demonstrate filling a glass syringe with vapor from an e-cigarette.
While previous studies have found that electronic cigarettes emit toxic compounds, a new study from Lawrence Berkeley National Laboratory (Berkeley Lab) has pinpointed the source of these emissions and shown how factors such as the temperature, type, and age of the device play a role in emission levels, information that could be valuable to both manufacturers and regulators seeking to minimize the health impacts of these increasingly popular devices.

Full articleJuly 27, 2016 05:24 PM621 views
Category: Environment


Researchers surveyed 75 plant species to identify top performing enzymes that will help increase the yields of staple food crops such as wheat.
Plant scientists at Lancaster University, with support from the University of Illinois, have made an important advance in understanding the natural diversity of a key plant enzyme which could help us address the looming threat of global food security.

Full articleJuly 27, 2016 05:24 PM432 views
Category: Microbiology


This image shows the mapping of the three distinct Zika virus DIII epitopes onto the mature virion.
Antibodies that specifically protect against Zika infection have been identified in mice, report Washington University School of Medicine in St. Louis researchers on July 27 in Cell. This is the second publication in recent weeks (another paper showing human Zika antibodies appeared in Science on July 14, DOI: 10.1126/science.aaf8505) that explores the surfaces that the antibodies target on the virus. The information will help inform the development of vaccines, diagnostics, and antibody-based prophylactic and therapeutic agents.

Full articleJuly 27, 2016 05:24 PM341 views
Category: Microbiology


This is the structure of the ZIKV helicase in complex with RNA.
Zika virus has now become a household word. It can cause microcephaly, a birth defect where a baby's head is smaller than usual. Additionally, it is associated with Guillain-Barré syndrome, a neurological disorder that could lead to paralysis and even death. However, how this microbe replicates in the infected cells remains a mystery. Now, an international team led by researchers from Tianjin University and Nankai University has unraveled the puzzle of how Zika virus replicates and published their finding in Springer's journal Protein & Cell.

Full articleJuly 26, 2016 03:43 PM839 views
Category: Molecular & Cell Biology


Roundworms (Caenorhabditis elegans) with a disabled eri-1 gene can lose their ability to control repetitive DNA. In the absence of eri-1, even two age-matched siblings can look dramatically different. Cancers arise in skin, muscle, liver or other types of tissue when one cell becomes different from its neighbors. Although biologists have learned a lot about how tissues form during development, very little is known about how two cells of the same tissue stay identical for an animal's entire lifetime.

Full articleJuly 26, 2016 03:43 PM769 views
Category: Health & Medicine

A study by researchers at Children's Hospital Los Angeles (CHLA), Brigham and Women's Hospital and the California Department of Public Health suggests that all babies with a known mutation for cystic fibrosis (CF) and second mutation called the 5T allele should receive additional screening in order to better predict the risk of developing CF later in life.

Full articleJuly 25, 2016 06:09 PM926 views
Category: Health & Medicine

Full-term babies receive natural protection from their mothers that helps them fight off dangerous infections. However, babies born prematurely lack protective intestinal bacteria and often are unable to be nursed, causing their infection-fighting capabilities to be underdeveloped. Now, researchers at the University of Missouri School of Medicine have found that a manufactured form of lactoferrin, a naturally occurring protein in breast milk, can help protect premature infants from a type of staph infection.

Full articleJuly 25, 2016 06:09 PM807 views
Category: Biotechnology

Scientists at The University of Nottingham have demonstrated for the first time that it is possible to selectively sequence fragments of DNA in real time, greatly reducing the time needed to analyse biological samples.

Full articleJuly 25, 2016 06:09 PM775 views
Category: Bioinformatics


This is an illustration of SRM peaks and a human face.
Reporting in the journal Cell, Senior Research Scientist Dr. Ulrike Kusebauch, of Institute for Systems Biology (ISB), describes the results of a collaboration between scientists at ISB, ETH Zurich and a number of other contributing institutes to develop the Human SRMAtlas, a compendium of proteomic assays for any human protein. The Human SRMAtlas is a compendium of highly specific mass spectrometry assays for the targeted identification and reproducible quantification of any protein in the predicted human proteome, including assays for many spliced variants, non-synonymous mutations and post-translational modifications. Using the technique called selected reaction monitoring, assays were developed with the use of 166,174 well-characterized, chemically synthesized proteotypic peptides. The SRMAtlas resource is freely publicly available at http://www.srmatlas.org and will equally benefit focused, hypothesis-driven and large proteome-scale studies. We expect this resource will significantly advance protein-based experimental biology to understand disease transitions and wellness trajectories because any human protein can now, in principle, be identified and quantified in any sample.

Full articleJuly 25, 2016 06:09 PM1309 views
Category: Stem Cell Research


The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
The fountain of youth may reside in an embryonic stem cell gene named Nanog.

Full articleJuly 25, 2016 06:09 PM744 views

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