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Category: Molecular & Cell Biology


Stylized graphic of SEC-SAXS data (with cyan cross-section showing the elution profile and magenta cross-section showing scattering profile) and the structure of the activated phenylalanine hydroxylase
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health. The enzyme, phenylalanine hydroxylase, turns the essential amino acid phenylalanine -- found in eggs, beef and many other foods and as an additive in diet soda -- into tyrosine, a precursor for multiple important neurotransmitters.

Full articleMay 25, 2016 05:44 PM971 views
Category: Molecular & Cell Biology

A new study from MIT neuroscientists reveals that a gene mutation associated with autism plays a critical role in the formation and maturation of synapses -- the connections that allow neurons to communicate with each other.

Full articleMay 25, 2016 05:44 PM999 views
Category: Bioinformatics


This image shows a range of vertebrate the G10K members are working on: Bird - Ruby-throated Hummingbird; Reptile - Green Anole; Fish - Spotted Gar; Mammal - Koala
The Genome Analysis Centre (TGAC) are to hold the biannual Genome 10K Conference on 29 August - 1 September 2017.

Full articleMay 25, 2016 05:44 PM847 views
Category: Health & Medicine

The National Myelodysplastic Syndromes Natural History Study (The National MDS Study) is underway, the ECOG-ACRIN Cancer Research Group and its collaborators announced today. This new study, funded by the National Institutes of Health's National Heart, Lung, and Blood Institute (NHLBI), and performed in collaboration with the National Cancer Institute (NCI), will collect detailed information and biological samples from 2000 adults with myelodysplastic syndromes (MDS) and 500 more patients receiving care for a persistent low red blood cell count (anemia) that cannot be explained. Its purpose is to build a national resource to be used by scientists in future research.

Full articleMay 25, 2016 05:44 PM907 views
Category: Molecular & Cell Biology

Unlike aspirin, bone marrow doesn't come with a neatly printed label with dosage instructions. However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

Full articleMay 25, 2016 05:44 PM786 views
Category: AIDS & HIV

Viruses attack cells and commandeer their machinery in a complex and carefully orchestrated invasion. Scientists have longed probed this process for insights into biology and disease, but essential details still remain out of reach.

Full articleMay 24, 2016 06:13 PM1094 views
Category: Molecular & Cell Biology


These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end...
A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

Full articleMay 24, 2016 06:13 PM992 views
Category: Bioinformatics

Whole-exome sequencing of both colorectal adenomas (precancers often called polyps) and intestinal mucosa at risk for developing into adenomas from patients with familial adenomatous polyposis (FAP) has generated a comprehensive picture of the genomic alterations that characterize the evolution of normal mucosa to precancer.

Full articleMay 24, 2016 06:13 PM824 views
Category: Health & Medicine

A change in diet can improve the lives of those diagnosed with a common, but hard-to-treat gut disorder.

Full articleMay 24, 2016 06:13 PM765 views
Category: Molecular & Cell Biology

Voltage-gated calcium channels open in unison, rather than independently, to allow calcium ions into and activate excitable cells such as neurons and muscle cells, researchers with UC Davis Health System and the University of Washington have found.

Full articleMay 18, 2016 07:44 PM1812 views
Category: AIDS & HIV

Acute HIV infection (AHI) contributes significantly to HIV transmission and may be important for intervention strategies seeking to reduce incidence and achieve a functional cure. In a study by the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, published in The New England Journal of Medicine, scientists enrolled and intensively followed a cohort of high-risk individuals, tracking their HIV status and characterizing the disease through the acute stages of HIV infection.

Full articleMay 18, 2016 07:44 PM1673 views
Category: Health & Medicine

Some of the final cases of Ebola in Sierra Leone were transmitted via unconventional routes, such as semen and breastmilk, according to the largest analysis to date of the tail-end of the epidemic.

Full articleMay 18, 2016 07:44 PM1784 views
Category: Molecular & Cell Biology

Retroviral DNAs integrate into host genomes, but their expression is normally repressed by cellular defense mechanisms. As an Ludwig-Maximilians-Universitaet (LMU) in Munich team now shows, when these measures fail, accumulation of viral proteins may trigger programmed cell death.

Full articleMay 17, 2016 06:35 PM1755 views
Category: Biology


Male and female worms engage in different behaviors, which may result from sex-specific wiring patterns in the brain.
Nematode worms may not be from Mars or Venus, but they do have sex-specific circuits in their brains that cause the males and females to act differently. According to new research published in Nature, scientists have determined how these sexually dimorphic (occurring in either males or females) connections arise in the worm nervous system. The research was funded by the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Full articleMay 16, 2016 01:47 PM2368 views

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