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Category: Bioinformatics

Associate Professor of Anthropology Ripan Malhi was a senior coauthor among an international team of researchers, who clarified the history of early migration to the Americas
The first human inhabitants of the Americas lived in a time thousands of years before the first written records, and the story of their transcontinental migration is the subject of ongoing debate and active research. A study by multi-institutional, international collaboration of researchers, published this week in Science (DOI: 10.1126/science.aab3884) presents strong evidence, gleaned from ancient and modern DNA samples, that the ancestry of all Native Americans can be traced back to a single migration event, with subsequent gene flow between some groups and populations that are currently located in East Asia and Australia.

Full articleJuly 27, 2015 04:22 PM484 views
Category: Health & Medicine

This illustration shows how the protein receptor CD68 acts as a gateway for a malaria parasite (sporozoite) to enter the liver through a Kupffer cell, as revealed by Cha et...
Scientists uncover a port of liver entry for malaria parasites in a report published in The Journal of Experimental Medicine. If these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.

Full articleJuly 27, 2015 04:22 PM267 views
Category: Health & Medicine

Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.

Full articleJuly 27, 2015 04:22 PM351 views
Category: Molecular & Cell Biology

A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies.

Full articleJuly 27, 2015 04:22 PM407 views
Category: Biotechnology

Some DNA sequences appear multiple times in the genome. Here, an RNA guide probe labels repetitive regions in the nucleus of a Xenopus laevis sperm.
University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA.

Full articleJuly 23, 2015 06:30 PM1291 views
Category: Molecular & Cell Biology

This is an example of hierarchical folded package of globule.
A group of researchers from the Lomonosov Moscow State University tried to address one of the least understood issues in the modern molecular biology, namely, how do strands of DNA pack themselves into the cell nucleus. Scientists concluded that packing of the genome in a special state called "fractal globule", apart from other known advantages of this state, allows the genetic machinery of the cell to operate with maximum speed due to comperatively rapid thermal diffusion. The article describing their results was published in Physical Review Letters.

Full articleJuly 23, 2015 06:30 PM941 views
Category: Molecular & Cell Biology

Pharmaceutical sciences researchers at Washington State University have discovered a protein's previously unknown role in cell division.

Full articleJuly 23, 2015 06:30 PM910 views
Category: Bioinformatics

Researchers at the Babraham Institute and Cambridge Systems Biology Centre, University of Cambridge have shown that yeast can modify their genomes to take advantage of an excess of calories in the environment and attain optimal growth.

Full articleJuly 21, 2015 06:49 PM1391 views
Category: Molecular & Cell Biology

Swedish researchers at Uppsala University and the Karolinska Institute have found that genes that control the biological clocks in cells throughout the body are altered after losing a single night of sleep, in a study that is to be published in the Journal of Clinical Endocrinology and Metabolism.

July 21, 2015 06:49 PM1399 views
Category: Molecular & Cell Biology

Researchers have shown that the levels of two proteins present in blood and cerebrospinal fluid increase significantly at different time points following traumatic brain injury (TBI), confirming their potential value as biomarkers of trauma-related brain damage. The researchers linked the changes in circulating UCH-L1 and GFAP proteins in rats to brain tissue damage and neuronal degeneration seen on examination of the rat brains and present their findings in an article published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Neurotrauma website.

Full articleJuly 21, 2015 06:49 PM1076 views
Category: Molecular & Cell Biology

Research findings obtained over the past decades increasingly indicate that stored memories are coded as permanent changes of neuronal communciation and the strength of neuronalinterconnections. The learning process evokes a specific pattern of electrical activity in these cells, which influences the response behavior to incoming signals, the expression of genes and the cellular morphology beyond the learning process itself.

Full articleJuly 20, 2015 06:26 PM1563 views
Category: Molecular & Cell Biology

Researcher Marie Hjelmseth Aune at CEMIR, the Centre of Molecular Inflammation Research at the Norwegian University of Science and Technology, looks at a macrophage engulfing an invading bacterium.
The human immune system is a powerful and wonderful creation. If you cut your skin, your body mobilizes a series of different proteins and cells to heal the cut. If you are infected by a virus or bacteria, your immune system responds with a series of cells that attack the invader and neutralize it.

Full articleJuly 20, 2015 06:26 PM1279 views
Category: Molecular & Cell Biology

DNA, the molecular foundation of life, has new tricks up its sleeve. The four bases from which it is composed snap together like jigsaw pieces and can be artificially manipulated to construct endlessly varied forms in two and three dimensions. The technique, known as DNA origami, promises to bring futuristic microelectronics and biomedical innovations to market.

Full articleJuly 20, 2015 06:26 PM1218 views
Category: Biotechnology

CRISPR/Cas9 is a gene-editing tool that can target a particular segment of DNA in living cells and replace it with a new genetic sequence.
Researchers at Harvard University and the University of California, San Diego, have developed a new user-friendly resource to accompany the powerful gene editing tool called CRISPR/Cas9, which has been widely adopted to make precise, targeted changes in DNA. This breakthrough has the potential to facilitate new discoveries in gene therapies and basic genetics research. The research was published in the July 13 issue of Nature Methods.

Full articleJuly 16, 2015 06:43 PM2165 views

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